Dominant Negative α-Subunit of FTase Inhibits Effects of Insulin and IGF-I in MCF-7 Cells
We recently designed a dominant negative (DN) farnesyltransferase (FTase)/geranyl-gerahyltransferase I (GGTase I) α-subunit that when expressed in vascular smooth muscle cells decreased insulin-stimulated phosphorylation of FTase, FTase activity, amounts of farnesylated p21Ras, DNA synthesis, and ce...
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Published in | Biochemical and biophysical research communications Vol. 291; no. 3; pp. 458 - 465 |
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Main Authors | , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.03.2002
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Abstract | We recently designed a dominant negative (DN) farnesyltransferase (FTase)/geranyl-gerahyltransferase I (GGTase I) α-subunit that when expressed in vascular smooth muscle cells decreased insulin-stimulated phosphorylation of FTase, FTase activity, amounts of farnesylated p21Ras, DNA synthesis, and cell migration. Currently, we explored the inhibitory effects of DN FTase/GGTase I α-subunit in MCF-7 cells on IGF-1- and insulin-stimulated DNA synthesis and cell proliferation. Expression of the DN FTase/GGTase I α-subunit completely blocked IGF-1- and insulin-stimulated BrdU incorporation and cell count. DN FTase/GGTase I α-subunit inhibited insulin-stimulated phosphorylation of FTase/GGTase I α-subunit, FTase and GGTase I activity, and prenylation of p21Ras and RhoA. Expression of DN FTase/GGTase I α-subunit diminished IGF-1- and insulin-stimulated phosphorylation of ERK (extracellular signal-regulated kinase), but had no effect on IGF-1- and insulin-stimulated phosphorylation of Akt. Taken together, these data suggest that DN FTase/GGTase I α-subunit can assuage the mitogenic effects of IGF-1 and insulin on MCF-7 breast cancer cells. |
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AbstractList | We recently designed a dominant negative (DN) farnesyltransferase (FTase)/geranyl-gerahyltransferase I (GGTase I) alpha-subunit that when expressed in vascular smooth muscle cells decreased insulin-stimulated phosphorylation of FTase, FTase activity, amounts of farnesylated p21Ras, DNA synthesis, and cell migration. Currently, we explored the inhibitory effects of DN FTase/GGTase I alpha-subunit in MCF-7 cells on IGF-1- and insulin-stimulated DNA synthesis and cell proliferation. Expression of the DN FTase/GGTase I alpha-subunit completely blocked IGF-1- and insulin-stimulated BrdU incorporation and cell count. DN FTase/GGTase I alpha-subunit inhibited insulin-stimulated phosphorylation of FTase/GGTase I alpha-subunit, FTase and GGTase I activity, and prenylation of p21Ras and RhoA. Expression of DN FTase/GGTase I alpha-subunit diminished IGF-1- and insulin-stimulated phosphorylation of ERK (extracellular signal-regulated kinase), but had no effect on IGF-1- and insulin-stimulated phosphorylation of Akt. Taken together, these data suggest that DN FTase/GGTase I alpha-subunit can assuage the mitogenic effects of IGF-1 and insulin on MCF-7 breast cancer cells. We recently designed a dominant negative (DN) farnesyltransferase (FTase)/geranyl-geranyltransferase I (GGTase I) alpha -subunit that when expressed in vascular smooth muscle cells decreased insulin-stimulated phosphorylation of FTase, FTase activity, amounts of farnesylated p21Ras, DNA synthesis, and cell migration. Currently, we explored the inhibitory effects of DN FTase/GGTase I alpha -subunit in MCF-7 cells on IGF-1- and insulin-stimulated DNA synthesis and cell proliferation. Expression of the DN FTase/GGTase I alpha -subunit completely blocked IGF-1- and insulin-stimulated BrdU incorporation and cell count. DN FTase/GGTase I alpha -subunit inhibited insulin-stimulated phosphorylation of FTase/GGTase I alpha -subunit, FTase and GGTase I activity, and prenylation of p21Ras and RhoA. Expression of DN FTase/GGTase I alpha -subunit diminished IGF-1- and insulin-stimulated phosphorylation of ERK (extracellular signal-regulated kinase), but had no effect on IGF-1- and insulin-stimulated phosphorylation of Akt. Taken together, these data suggest that DN FTase/GGTase I alpha -subunit can assuage the mitogenic effects of IGF-1 and insulin on MCF-7 breast cancer cells. We recently designed a dominant negative (DN) farnesyltransferase (FTase)/geranyl-gerahyltransferase I (GGTase I) α-subunit that when expressed in vascular smooth muscle cells decreased insulin-stimulated phosphorylation of FTase, FTase activity, amounts of farnesylated p21Ras, DNA synthesis, and cell migration. Currently, we explored the inhibitory effects of DN FTase/GGTase I α-subunit in MCF-7 cells on IGF-1- and insulin-stimulated DNA synthesis and cell proliferation. Expression of the DN FTase/GGTase I α-subunit completely blocked IGF-1- and insulin-stimulated BrdU incorporation and cell count. DN FTase/GGTase I α-subunit inhibited insulin-stimulated phosphorylation of FTase/GGTase I α-subunit, FTase and GGTase I activity, and prenylation of p21Ras and RhoA. Expression of DN FTase/GGTase I α-subunit diminished IGF-1- and insulin-stimulated phosphorylation of ERK (extracellular signal-regulated kinase), but had no effect on IGF-1- and insulin-stimulated phosphorylation of Akt. Taken together, these data suggest that DN FTase/GGTase I α-subunit can assuage the mitogenic effects of IGF-1 and insulin on MCF-7 breast cancer cells. |
Author | Goalstone, Marc Lee Solomon, Curtis Scott |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11855811$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/S0076-6879(01)32196-1 10.1172/JCI114868 10.1161/01.RES.87.9.746 10.1006/bbrc.2001.5142 10.1074/jbc.M006741200 10.2337/diacare.24.3.588 10.1146/annurev.bi.65.070196.001325 10.1677/joe.0.1520039 10.1074/jbc.271.44.27585 10.1016/0167-4838(94)90089-2 10.1093/jnci/89.18.1360 10.1172/JCI6609 10.1007/BF00052777 10.1002/(SICI)1097-4644(19980801)70:2<268::AID-JCB12>3.0.CO;2-J 10.1006/exmp.1999.2294 10.1038/310583a0 10.1021/bi00070a028 10.1210/endo.138.12.5621 10.1016/0092-8674(91)90460-G 10.1210/endo.138.5.5240 10.1007/s001250051156 10.1073/pnas.87.19.7541 10.1007/s001250051393 10.1007/s001250051387 10.1073/pnas.86.21.8323 10.1128/MCB.14.7.4902 10.1002/(SICI)1097-0215(19991008)83:2<283::AID-IJC22>3.0.CO;2-6 10.1023/A:1006018922878 10.1093/hmg/10.6.605 10.1136/mp.54.3.149 10.1210/endo.139.10.6270 10.1093/jnci/93.10.783 10.1074/jbc.M104416200 10.1074/jbc.273.37.23892 10.1006/bbrc.1997.7413 10.1023/A:1008966623901 10.1186/bcr50 10.1074/jbc.M004798200 10.1016/S0021-9258(18)98729-6 10.1016/S0021-9258(18)77164-0 10.1074/jbc.M009443200 10.1152/ajpendo.2001.281.2.E217 |
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Keywords | geranylgeranyltransferase I MCF-7 cells farnesyltransferase insulin dominant negative α-subunit |
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References | Solomon, Goalstone (RF24) 2001; 285 Seabra, Reiss, Casey, Brown, Goldstein (RF18) 1991; 65 Caplin, Hettich, Marshall (RF19) 1994; 1205 Chappell, Leitner, Solomon, Golovchenko, Goalstone, Draznin (RF26) 2001; 276 Goalstone, Leitner, Draznin (RF37) 1997; 239 Goalstone, Draznin (RF25) 1996; 271 Zhang, Yee (RF5) 2000; 2 Zhang, Casey (RF15) 1996; 65 Ish-Shalom, Christoffersen, Vorwerk, Sacerdoti-Sierra, Shymko, Naor, DeMeyts (RF32) 1997; 40 Schaber, O'Hara, Garshy, Mosser, Bergstrom, Moores, Marshall, Frieman, Dixon, Gibbs (RF12) 1990; 265 Cheatham, Vlahos, Cheatham, Wang, Blenis, Kahn (RF6) 1994; 14 Kirschmeier, Shyte, Wilson, Bishop, Pai (RF46) 2001; 232 Weng, Smith, Brown, Eng (RF43) 2001; 10 Gliozzo, Sung, Scalia, Papa, Frasca, Sciacca, Giorgino, Milazzo, Goldfine, Vigneri, Pezzino (RF1) 1998; 70 Chappell, Golovchenko, Wall, Stjernholm, Leitner, Goalstone, Draznin (RF22) 2000; 275 Leitner, Kline, Carel, Goalstone, Draznin (RF9) 1997; 138 Golovchenko, Goalstone, Watson, Brownlee, Draznin (RF33) 2000; 87 Willumsen, Christensen, Hubbert, Papageorge, Lowy (RF13) 1984; 310 Omer, Kral, Diehl, Prendergast, Powers, Allen, Gibbs, Kohl (RF16) 1993; 32 Goalstone, Leitner, Berhanu, Sharma, Olefsky, Draznin (RF36) 2001; 276 Lee, Weng, Jackson, Yee (RF41) 1997; 152 Papa, Pezzino, Costantino, Belfiore, Giuffrida, Frittitta, Vannelli, Brand, Vigneri (RF39) 1990; 85 Wideroff, Gridley, Mellemkjaer, Chow, Linet, Keehn, Borch-Johnsen, Olsen (RF38) 1997; 89 Manne, Roberts, Tobin, O'Rourke, De Virgilio, Meyers, Ahmed, Kurz, Resh, Kung, Barbicid (RF14) 1990; 87 Goalstone, Natarajan, Standley, Walsh, Leitner, Carel, Scott, Nadler, Sowers, Draznin (RF20) 1998; 139 Hsing, Chua, Gao, Gentzschein, Chang, Deng, Stanczyk (RF35) 2001; 93 LeRoith, Zick (RF30) 2001; 24 Cheatham, Kahn (RF7) 1995; 16 Lobell, Kohl (RF45) 1998; 17 Bhalla, Joshi, Vohra, Singh, Ganguly (RF2) 2000; 68 Stephens, Thureen, Goalstone, Anderson, Leitner, Hay, Draznin (RF29) 2001; 281 Giovannucci (RF34) 1995; 6 Moores, Schaber, Mosser, Rands, O'Hara, Garsky, Marshall, Pompliano, Gibbs (RF11) 1991; 266 Goalstone, Carel, Leitner, Draznin (RF17) 1997; 138 Dupont, LeRoith (RF3) 2001; 54 Muti, Stanulla, Micheli, Krogh, Freudenheim, Yang, Schunemann, Trevisan, Berrino (RF4) 2000; 11 Virkamaki, Ueki, Kahn (RF31) 1999; 103 Goalstone, Leitner, Wall, Dolgonos, Rother, Accili, Draznin (RF21) 1998; 273 Milazzo, Giorgino, Damante, Sung, Stampfer, Vigneri, Goldfine, Belfiore (RF40) 1992; 52 Casey, Solski, Der, Buss (RF10) 1989; 86 Goalstone, Wall, Leitner, Kurowski, Ruderman, Pan, Ivy, Moller, Draznin (RF28) 1999; 42 el-Tanani, Green (RF42) 1996; 121 Goalstone, Leitner, Draznin (RF23) 1999 Prevost, Pradines, Viossat, Brezak, Miquil, Lonchampt, Kasprzyk, Favre, Pignol, Le Breton, Dong, Morgan (RF44) 1999; 83 Dupont, Karas, LeRoith (RF27) 2000; 275 White (RF8) 1997; 40 Casey (10.1006/bbrc.2002.6471_RF10) 1989; 86 Zhang (10.1006/bbrc.2002.6471_RF5) 2000; 2 el-Tanani (10.1006/bbrc.2002.6471_RF42) 1996; 121 Goalstone (10.1006/bbrc.2002.6471_RF21) 1998; 273 Cheatham (10.1006/bbrc.2002.6471_RF7) 1995; 16 Goalstone (10.1006/bbrc.2002.6471_RF28) 1999; 42 Papa (10.1006/bbrc.2002.6471_RF39) 1990; 85 Kirschmeier (10.1006/bbrc.2002.6471_RF46) 2001; 232 Goalstone (10.1006/bbrc.2002.6471_RF23) 1999 Moores (10.1006/bbrc.2002.6471_RF11) 1991; 266 Manne (10.1006/bbrc.2002.6471_RF14) 1990; 87 Muti (10.1006/bbrc.2002.6471_RF4) 2000; 11 Cheatham (10.1006/bbrc.2002.6471_RF6) 1994; 14 White (10.1006/bbrc.2002.6471_RF8) 1997; 40 Caplin (10.1006/bbrc.2002.6471_RF19) 1994; 1205 Chappell (10.1006/bbrc.2002.6471_RF26) 2001; 276 Solomon (10.1006/bbrc.2002.6471_RF24) 2001; 285 Milazzo (10.1006/bbrc.2002.6471_RF40) 1992; 52 Lee (10.1006/bbrc.2002.6471_RF41) 1997; 152 Hsing (10.1006/bbrc.2002.6471_RF35) 2001; 93 Weng (10.1006/bbrc.2002.6471_RF43) 2001; 10 Giovannucci (10.1006/bbrc.2002.6471_RF34) 1995; 6 Goalstone (10.1006/bbrc.2002.6471_RF20) 1998; 139 Goalstone (10.1006/bbrc.2002.6471_RF36) 2001; 276 Virkamaki (10.1006/bbrc.2002.6471_RF31) 1999; 103 Prevost (10.1006/bbrc.2002.6471_RF44) 1999; 83 Dupont (10.1006/bbrc.2002.6471_RF3) 2001; 54 Schaber (10.1006/bbrc.2002.6471_RF12) 1990; 265 Zhang (10.1006/bbrc.2002.6471_RF15) 1996; 65 Omer (10.1006/bbrc.2002.6471_RF16) 1993; 32 Seabra (10.1006/bbrc.2002.6471_RF18) 1991; 65 Dupont (10.1006/bbrc.2002.6471_RF27) 2000; 275 Lobell (10.1006/bbrc.2002.6471_RF45) 1998; 17 Willumsen (10.1006/bbrc.2002.6471_RF13) 1984; 310 Chappell (10.1006/bbrc.2002.6471_RF22) 2000; 275 Wideroff (10.1006/bbrc.2002.6471_RF38) 1997; 89 Stephens (10.1006/bbrc.2002.6471_RF29) 2001; 281 Bhalla (10.1006/bbrc.2002.6471_RF2) 2000; 68 Leitner (10.1006/bbrc.2002.6471_RF9) 1997; 138 Golovchenko (10.1006/bbrc.2002.6471_RF33) 2000; 87 Goalstone (10.1006/bbrc.2002.6471_RF37) 1997; 239 LeRoith (10.1006/bbrc.2002.6471_RF30) 2001; 24 Ish-Shalom (10.1006/bbrc.2002.6471_RF32) 1997; 40 Goalstone (10.1006/bbrc.2002.6471_RF25) 1996; 271 Goalstone (10.1006/bbrc.2002.6471_RF17) 1997; 138 Gliozzo (10.1006/bbrc.2002.6471_RF1) 1998; 70 |
References_xml | – volume: 32 start-page: 5167 year: 1993 end-page: 5176 ident: RF16 article-title: Characterization of recombinant human farnesyl-protein transferase: Cloning, expresion, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases publication-title: Biochemistry contributor: fullname: Kohl – volume: 1205 start-page: 39 year: 1994 end-page: 48 ident: RF19 article-title: Substrate characterization of the publication-title: Biochim. Biophys. Acta contributor: fullname: Marshall – volume: 276 start-page: 38023 year: 2001 end-page: 38028 ident: RF26 article-title: Effect of insulin on cell cycle pregression in MCF-7 breast cancer cells: Direct and potentiating influence publication-title: J. Biol. Chem. contributor: fullname: Draznin – volume: 87 start-page: 746 year: 2000 end-page: 752 ident: RF33 article-title: Hyperinsulinemia enhances transcriptional activity of NFkB induced by angiotensin II, hyperglycemia and advanced glycosylation end products in vascular smooth muscle cells publication-title: Circ. Res. contributor: fullname: Draznin – volume: 310 start-page: 583 year: 1984 end-page: 586 ident: RF13 article-title: The p21 ras C-terminus is required for transformation and membrane association publication-title: Nature contributor: fullname: Lowy – volume: 139 start-page: 4067 year: 1998 end-page: 4072 ident: RF20 article-title: Insulin potentiates platelet-derived growth factor action in vascular smooth muscle cells publication-title: Endocrinology contributor: fullname: Draznin – volume: 10 start-page: 605 year: 2001 end-page: 616 ident: RF43 article-title: PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Sos complex formation in breast cancer model publication-title: Hum. Mol. Genet. contributor: fullname: Eng – volume: 70 start-page: 268 year: 1998 end-page: 280 ident: RF1 article-title: Insulin-stimulated cell growth in insulin receptor substrate-1 deficient ZR-75–1 cells is mediated by a phosphatidylinositol-3-kinase-independent pathway publication-title: J. Cell. Biochem. contributor: fullname: Pezzino – volume: 16 start-page: 117 year: 1995 end-page: 142 ident: RF7 article-title: Insulin action and the insulin signaling network publication-title: Endocr. Rev. contributor: fullname: Kahn – volume: 138 start-page: 2211 year: 1997 end-page: 2214 ident: RF9 article-title: Hyperinsulinemia potentiates activation of p21Ras by growth factors publication-title: Endocrinology contributor: fullname: Draznin – volume: 271 start-page: 27585 year: 1996 end-page: 27589 ident: RF25 article-title: Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes publication-title: J. Biol. Chem. contributor: fullname: Draznin – volume: 6 start-page: 164 year: 1995 end-page: 179 ident: RF34 article-title: Insulin and colon cancer publication-title: Cancer Causes Control contributor: fullname: Giovannucci – volume: 52 start-page: 3924 year: 1992 end-page: 3930 ident: RF40 article-title: Insulin receptor expression and function in human breast cancer cell lines publication-title: Cancer Res. contributor: fullname: Belfiore – volume: 285 start-page: 161 year: 2001 end-page: 166 ident: RF24 article-title: Dominant negative farnesyltransferase α-subunit inhibits insulin mitogenic effects publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Goalstone – volume: 103 start-page: 931 year: 1999 end-page: 943 ident: RF31 article-title: Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance publication-title: J. Clin. Invest. contributor: fullname: Kahn – volume: 87 start-page: 7541 year: 1990 end-page: 7545 ident: RF14 article-title: Identification of and preliminary characterization of protein-cysteine farnesyltransferase publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Barbicid – volume: 265 start-page: 14701 year: 1990 end-page: 14704 ident: RF12 article-title: Polyisoprenylation of ras publication-title: J. Biol. Chem. contributor: fullname: Gibbs – volume: 266 start-page: 4603 year: 1991 end-page: 4610 ident: RF11 article-title: Sequence dependence of protein isoprenylation publication-title: J. Biol. Chem. contributor: fullname: Gibbs – volume: 54 start-page: 149 year: 2001 end-page: 154 ident: RF3 article-title: Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: New insights into their synergistic effects publication-title: Mol. Pathol. contributor: fullname: LeRoith – volume: 40 start-page: S2 year: 1997 end-page: S17 ident: RF8 article-title: The insulin signaling system and the IRS protein publication-title: Diabetologia contributor: fullname: White – volume: 275 start-page: 35893 year: 2000 end-page: 35901 ident: RF27 article-title: The potentiation of estrogen on insulin-like growth factor I action in MCF-7 cycle components publication-title: J. Biol. Chem. contributor: fullname: LeRoith – volume: 17 start-page: 203 year: 1998 end-page: 210 ident: RF45 article-title: Pre-clinical development of farnesyltransferase inhibitors publication-title: Cancer Metast. Rev. contributor: fullname: Kohl – volume: 11 start-page: 721 year: 2000 end-page: 730 ident: RF4 article-title: Markers of insulin resistance and sex steroid hormone activity in relation to breast cancer risk: A prospective analysis of abdominal adiposity, sebum production, and hirsutism publication-title: Cancer Causes Control contributor: fullname: Berrino – volume: 138 start-page: 5119 year: 1997 end-page: 5124 ident: RF17 article-title: Insulin stimulates the phosphorylation and activity of farnesyltransferase via the Ras-mitogen-activated protein kinase pathway publication-title: Endocrinology contributor: fullname: Draznin – volume: 121 start-page: 29 year: 1996 end-page: 35 ident: RF42 article-title: Insulin/IGF-1 modulation of the expression of two estrogen-induced genes in MCF-7 cells publication-title: Endocrinology contributor: fullname: Green – volume: 42 start-page: 310 year: 1999 end-page: 316 ident: RF28 article-title: Increased amounts of farnesylated p21Ras in tissues of hyperinsulinemic animals publication-title: Diabetologia contributor: fullname: Draznin – volume: 65 start-page: 241 year: 1996 end-page: 269 ident: RF15 article-title: Protein prenylation: Molecular mechanisms and functional consequences publication-title: Annu Rev. Biochem. contributor: fullname: Casey – volume: 86 start-page: 8323 year: 1989 end-page: 8327 ident: RF10 article-title: p21 ras is modified by a farnesyl isoprenoid publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Buss – volume: 14 start-page: 4902 year: 1994 end-page: 4911 ident: RF6 article-title: Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation publication-title: Mol. Cell. Biol. contributor: fullname: Kahn – volume: 24 start-page: 588 year: 2001 end-page: 597 ident: RF30 article-title: Recent advances in our understanding of insulin action and insulin resistance publication-title: Diabetes Care contributor: fullname: Zick – volume: 273 start-page: 23892 year: 1998 end-page: 23896 ident: RF21 article-title: Effect of insulin on farnesyltransferase: Specificity of insulin action and potentitation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor publication-title: J. Biol. Chem. contributor: fullname: Draznin – volume: 89 start-page: 1360 year: 1997 end-page: 1365 ident: RF38 article-title: Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark publication-title: J. Natl. Cancer Inst. contributor: fullname: Olsen – volume: 152 start-page: 39 year: 1997 end-page: 47 ident: RF41 article-title: Activation of estrogen receptor-mediated gene transcription by IGF-I in human breast cancer cells publication-title: J. Endocr. contributor: fullname: Yee – volume: 275 start-page: 31792 year: 2000 end-page: 31797 ident: RF22 article-title: Potentiation of Rho-A-mediated lysophophatidic acid activity by hyperinsulinemia publication-title: J. Biol. Chem. contributor: fullname: Draznin – volume: 40 start-page: 525 year: 1997 end-page: 531 ident: RF32 article-title: Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor publication-title: Diabetologia contributor: fullname: DeMeyts – volume: 65 start-page: 429 year: 1991 end-page: 434 ident: RF18 article-title: Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit publication-title: Cell contributor: fullname: Goldstein – volume: 2 start-page: 170 year: 2000 end-page: 175 ident: RF5 article-title: Tyrosine kinase signaling in breast cancer: Insulin-like growth factors and their receptors in breast cancer publication-title: Breast Cancer Res. contributor: fullname: Yee – start-page: 155 year: 1999 end-page: 173 ident: RF23 publication-title: Advancies in Molecular and Cellular Endocrinology contributor: fullname: Draznin – volume: 83 start-page: 283 year: 1999 end-page: 287 ident: RF44 article-title: Inhibition of human tumor cell growth publication-title: Int. J. Cancer contributor: fullname: Morgan – volume: 93 start-page: 783 year: 2001 end-page: 789 ident: RF35 article-title: Prostate cancer risk and serum levels of insulin and leptin: A population-based study publication-title: J. Natl. Cancer Inst. contributor: fullname: Stanczyk – volume: 281 start-page: E217 year: 2001 end-page: E223 ident: RF29 article-title: Fetal hyperinsulinemia increases farnesylation of p21Ras in fetal tissues publication-title: Am. J. Physiol. Endocrinol. Metab. contributor: fullname: Draznin – volume: 276 start-page: 12805 year: 2001 end-page: 12812 ident: RF36 article-title: Insulin signals to prenyltransferases via the Shc branch of intracellular signaling publication-title: J. Biol. Chem. contributor: fullname: Draznin – volume: 68 start-page: 124 year: 2000 end-page: 132 ident: RF2 article-title: Effect of growth factors on proliferation of normal, borderline, and malignant breast epithelial cells publication-title: Exp. Mol. Pathol. contributor: fullname: Ganguly – volume: 239 start-page: 42 year: 1997 end-page: 45 ident: RF37 article-title: GTP loading of farnesylated p21Ras by insulin at the plasma membrane publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Draznin – volume: 232 start-page: 115 year: 2001 end-page: 127 ident: RF46 article-title: prenylation analysis of ras and rho proteins publication-title: Methods Enzymol. contributor: fullname: Pai – volume: 85 start-page: 1503 year: 1990 end-page: 1510 ident: RF39 article-title: Elevated insulin receptor content in human breast cancer publication-title: J. Clin. Invest. contributor: fullname: Vigneri – volume: 232 start-page: 115 year: 2001 ident: 10.1006/bbrc.2002.6471_RF46 article-title: In vivo prenylation analysis of ras and rho proteins publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(01)32196-1 contributor: fullname: Kirschmeier – volume: 85 start-page: 1503 year: 1990 ident: 10.1006/bbrc.2002.6471_RF39 article-title: Elevated insulin receptor content in human breast cancer publication-title: J. Clin. Invest. doi: 10.1172/JCI114868 contributor: fullname: Papa – volume: 87 start-page: 746 year: 2000 ident: 10.1006/bbrc.2002.6471_RF33 article-title: Hyperinsulinemia enhances transcriptional activity of NFkB induced by angiotensin II, hyperglycemia and advanced glycosylation end products in vascular smooth muscle cells publication-title: Circ. Res. doi: 10.1161/01.RES.87.9.746 contributor: fullname: Golovchenko – volume: 285 start-page: 161 year: 2001 ident: 10.1006/bbrc.2002.6471_RF24 article-title: Dominant negative farnesyltransferase α-subunit inhibits insulin mitogenic effects publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.2001.5142 contributor: fullname: Solomon – volume: 275 start-page: 35893 year: 2000 ident: 10.1006/bbrc.2002.6471_RF27 article-title: The potentiation of estrogen on insulin-like growth factor I action in MCF-7 cycle components publication-title: J. Biol. Chem. doi: 10.1074/jbc.M006741200 contributor: fullname: Dupont – volume: 24 start-page: 588 year: 2001 ident: 10.1006/bbrc.2002.6471_RF30 article-title: Recent advances in our understanding of insulin action and insulin resistance publication-title: Diabetes Care doi: 10.2337/diacare.24.3.588 contributor: fullname: LeRoith – volume: 65 start-page: 241 year: 1996 ident: 10.1006/bbrc.2002.6471_RF15 article-title: Protein prenylation: Molecular mechanisms and functional consequences publication-title: Annu Rev. Biochem. doi: 10.1146/annurev.bi.65.070196.001325 contributor: fullname: Zhang – volume: 152 start-page: 39 year: 1997 ident: 10.1006/bbrc.2002.6471_RF41 article-title: Activation of estrogen receptor-mediated gene transcription by IGF-I in human breast cancer cells publication-title: J. Endocr. doi: 10.1677/joe.0.1520039 contributor: fullname: Lee – volume: 271 start-page: 27585 year: 1996 ident: 10.1006/bbrc.2002.6471_RF25 article-title: Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.44.27585 contributor: fullname: Goalstone – volume: 1205 start-page: 39 year: 1994 ident: 10.1006/bbrc.2002.6471_RF19 article-title: Substrate characterization of the Saccharomyces cerevisiae protein farnesyltransferase and type-I protein geranylgeranyltransferase publication-title: Biochim. Biophys. Acta doi: 10.1016/0167-4838(94)90089-2 contributor: fullname: Caplin – volume: 89 start-page: 1360 year: 1997 ident: 10.1006/bbrc.2002.6471_RF38 article-title: Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/89.18.1360 contributor: fullname: Wideroff – volume: 103 start-page: 931 year: 1999 ident: 10.1006/bbrc.2002.6471_RF31 article-title: Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance publication-title: J. Clin. Invest. doi: 10.1172/JCI6609 contributor: fullname: Virkamaki – volume: 6 start-page: 164 year: 1995 ident: 10.1006/bbrc.2002.6471_RF34 article-title: Insulin and colon cancer publication-title: Cancer Causes Control doi: 10.1007/BF00052777 contributor: fullname: Giovannucci – volume: 52 start-page: 3924 year: 1992 ident: 10.1006/bbrc.2002.6471_RF40 article-title: Insulin receptor expression and function in human breast cancer cell lines publication-title: Cancer Res. contributor: fullname: Milazzo – volume: 70 start-page: 268 year: 1998 ident: 10.1006/bbrc.2002.6471_RF1 article-title: Insulin-stimulated cell growth in insulin receptor substrate-1 deficient ZR-75–1 cells is mediated by a phosphatidylinositol-3-kinase-independent pathway publication-title: J. Cell. Biochem. doi: 10.1002/(SICI)1097-4644(19980801)70:2<268::AID-JCB12>3.0.CO;2-J contributor: fullname: Gliozzo – volume: 68 start-page: 124 year: 2000 ident: 10.1006/bbrc.2002.6471_RF2 article-title: Effect of growth factors on proliferation of normal, borderline, and malignant breast epithelial cells publication-title: Exp. Mol. Pathol. doi: 10.1006/exmp.1999.2294 contributor: fullname: Bhalla – volume: 310 start-page: 583 year: 1984 ident: 10.1006/bbrc.2002.6471_RF13 article-title: The p21 ras C-terminus is required for transformation and membrane association publication-title: Nature doi: 10.1038/310583a0 contributor: fullname: Willumsen – volume: 32 start-page: 5167 year: 1993 ident: 10.1006/bbrc.2002.6471_RF16 article-title: Characterization of recombinant human farnesyl-protein transferase: Cloning, expresion, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases publication-title: Biochemistry doi: 10.1021/bi00070a028 contributor: fullname: Omer – volume: 138 start-page: 5119 year: 1997 ident: 10.1006/bbrc.2002.6471_RF17 article-title: Insulin stimulates the phosphorylation and activity of farnesyltransferase via the Ras-mitogen-activated protein kinase pathway publication-title: Endocrinology doi: 10.1210/endo.138.12.5621 contributor: fullname: Goalstone – volume: 65 start-page: 429 year: 1991 ident: 10.1006/bbrc.2002.6471_RF18 article-title: Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit publication-title: Cell doi: 10.1016/0092-8674(91)90460-G contributor: fullname: Seabra – volume: 138 start-page: 2211 year: 1997 ident: 10.1006/bbrc.2002.6471_RF9 article-title: Hyperinsulinemia potentiates activation of p21Ras by growth factors publication-title: Endocrinology doi: 10.1210/endo.138.5.5240 contributor: fullname: Leitner – volume: 42 start-page: 310 year: 1999 ident: 10.1006/bbrc.2002.6471_RF28 article-title: Increased amounts of farnesylated p21Ras in tissues of hyperinsulinemic animals publication-title: Diabetologia doi: 10.1007/s001250051156 contributor: fullname: Goalstone – volume: 87 start-page: 7541 year: 1990 ident: 10.1006/bbrc.2002.6471_RF14 article-title: Identification of and preliminary characterization of protein-cysteine farnesyltransferase publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.87.19.7541 contributor: fullname: Manne – volume: 40 start-page: 525 year: 1997 ident: 10.1006/bbrc.2002.6471_RF32 article-title: Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor publication-title: Diabetologia doi: 10.1007/s001250051393 contributor: fullname: Ish-Shalom – volume: 40 start-page: S2 year: 1997 ident: 10.1006/bbrc.2002.6471_RF8 article-title: The insulin signaling system and the IRS protein publication-title: Diabetologia doi: 10.1007/s001250051387 contributor: fullname: White – volume: 86 start-page: 8323 year: 1989 ident: 10.1006/bbrc.2002.6471_RF10 article-title: p21 ras is modified by a farnesyl isoprenoid publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.86.21.8323 contributor: fullname: Casey – volume: 14 start-page: 4902 year: 1994 ident: 10.1006/bbrc.2002.6471_RF6 article-title: Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.14.7.4902 contributor: fullname: Cheatham – volume: 83 start-page: 283 year: 1999 ident: 10.1006/bbrc.2002.6471_RF44 article-title: Inhibition of human tumor cell growth in vitro and in vivo by a specific inhibitor of human farnesyltransferase: BIM-46068 publication-title: Int. J. Cancer doi: 10.1002/(SICI)1097-0215(19991008)83:2<283::AID-IJC22>3.0.CO;2-6 contributor: fullname: Prevost – volume: 17 start-page: 203 year: 1998 ident: 10.1006/bbrc.2002.6471_RF45 article-title: Pre-clinical development of farnesyltransferase inhibitors publication-title: Cancer Metast. Rev. doi: 10.1023/A:1006018922878 contributor: fullname: Lobell – volume: 10 start-page: 605 year: 2001 ident: 10.1006/bbrc.2002.6471_RF43 article-title: PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Sos complex formation in breast cancer model publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/10.6.605 contributor: fullname: Weng – start-page: 155 year: 1999 ident: 10.1006/bbrc.2002.6471_RF23 contributor: fullname: Goalstone – volume: 54 start-page: 149 year: 2001 ident: 10.1006/bbrc.2002.6471_RF3 article-title: Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: New insights into their synergistic effects publication-title: Mol. Pathol. doi: 10.1136/mp.54.3.149 contributor: fullname: Dupont – volume: 139 start-page: 4067 year: 1998 ident: 10.1006/bbrc.2002.6471_RF20 article-title: Insulin potentiates platelet-derived growth factor action in vascular smooth muscle cells publication-title: Endocrinology doi: 10.1210/endo.139.10.6270 contributor: fullname: Goalstone – volume: 93 start-page: 783 year: 2001 ident: 10.1006/bbrc.2002.6471_RF35 article-title: Prostate cancer risk and serum levels of insulin and leptin: A population-based study publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/93.10.783 contributor: fullname: Hsing – volume: 276 start-page: 38023 year: 2001 ident: 10.1006/bbrc.2002.6471_RF26 article-title: Effect of insulin on cell cycle pregression in MCF-7 breast cancer cells: Direct and potentiating influence publication-title: J. Biol. Chem. doi: 10.1074/jbc.M104416200 contributor: fullname: Chappell – volume: 273 start-page: 23892 year: 1998 ident: 10.1006/bbrc.2002.6471_RF21 article-title: Effect of insulin on farnesyltransferase: Specificity of insulin action and potentitation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.37.23892 contributor: fullname: Goalstone – volume: 239 start-page: 42 year: 1997 ident: 10.1006/bbrc.2002.6471_RF37 article-title: GTP loading of farnesylated p21Ras by insulin at the plasma membrane publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1997.7413 contributor: fullname: Goalstone – volume: 11 start-page: 721 year: 2000 ident: 10.1006/bbrc.2002.6471_RF4 article-title: Markers of insulin resistance and sex steroid hormone activity in relation to breast cancer risk: A prospective analysis of abdominal adiposity, sebum production, and hirsutism publication-title: Cancer Causes Control doi: 10.1023/A:1008966623901 contributor: fullname: Muti – volume: 2 start-page: 170 year: 2000 ident: 10.1006/bbrc.2002.6471_RF5 article-title: Tyrosine kinase signaling in breast cancer: Insulin-like growth factors and their receptors in breast cancer publication-title: Breast Cancer Res. doi: 10.1186/bcr50 contributor: fullname: Zhang – volume: 121 start-page: 29 year: 1996 ident: 10.1006/bbrc.2002.6471_RF42 article-title: Insulin/IGF-1 modulation of the expression of two estrogen-induced genes in MCF-7 cells publication-title: Endocrinology contributor: fullname: el-Tanani – volume: 16 start-page: 117 year: 1995 ident: 10.1006/bbrc.2002.6471_RF7 article-title: Insulin action and the insulin signaling network publication-title: Endocr. Rev. contributor: fullname: Cheatham – volume: 275 start-page: 31792 year: 2000 ident: 10.1006/bbrc.2002.6471_RF22 article-title: Potentiation of Rho-A-mediated lysophophatidic acid activity by hyperinsulinemia publication-title: J. Biol. Chem. doi: 10.1074/jbc.M004798200 contributor: fullname: Chappell – volume: 266 start-page: 4603 year: 1991 ident: 10.1006/bbrc.2002.6471_RF11 article-title: Sequence dependence of protein isoprenylation publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)98729-6 contributor: fullname: Moores – volume: 265 start-page: 14701 year: 1990 ident: 10.1006/bbrc.2002.6471_RF12 article-title: Polyisoprenylation of ras in vivo by a farnesyl-protein transferase publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)77164-0 contributor: fullname: Schaber – volume: 276 start-page: 12805 year: 2001 ident: 10.1006/bbrc.2002.6471_RF36 article-title: Insulin signals to prenyltransferases via the Shc branch of intracellular signaling publication-title: J. Biol. Chem. doi: 10.1074/jbc.M009443200 contributor: fullname: Goalstone – volume: 281 start-page: E217 year: 2001 ident: 10.1006/bbrc.2002.6471_RF29 article-title: Fetal hyperinsulinemia increases farnesylation of p21Ras in fetal tissues publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.2001.281.2.E217 contributor: fullname: Stephens |
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Snippet | We recently designed a dominant negative (DN) farnesyltransferase (FTase)/geranyl-gerahyltransferase I (GGTase I) α-subunit that when expressed in vascular... We recently designed a dominant negative (DN) farnesyltransferase (FTase)/geranyl-gerahyltransferase I (GGTase I) alpha-subunit that when expressed in vascular... We recently designed a dominant negative (DN) farnesyltransferase (FTase)/geranyl-geranyltransferase I (GGTase I) alpha -subunit that when expressed in... |
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SubjectTerms | Akt protein Alkyl and Aryl Transferases - chemistry Alkyl and Aryl Transferases - genetics Alkyl and Aryl Transferases - metabolism Alkyl and Aryl Transferases - physiology Breast Neoplasms - enzymology Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - therapy Cell Division DNA, Neoplasm - biosynthesis dominant negative α-subunit farnesyltransferase Female geranyl-geranyltransferase geranylgeranyltransferase I Humans insulin Insulin - pharmacology Insulin Antagonists - pharmacology Insulin-Like Growth Factor I - antagonists & inhibitors MCF-7 cells Mutation Phosphorylation Protein Prenylation Protein Subunits Proto-Oncogene Proteins p21(ras) - metabolism rhoA GTP-Binding Protein - metabolism Tumor Cells, Cultured |
Title | Dominant Negative α-Subunit of FTase Inhibits Effects of Insulin and IGF-I in MCF-7 Cells |
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