Formulation and optimization of albumin nanoparticles loaded ivabradine hydrochloride using response surface design

• Published in: Journal of drug delivery science and technology Vol. 63; p. 102461
• Main Authors: Jenita, J. Josephine Leno, Tibrewal, Richa, Rathore, Seema S., Manjula, D., Barnabas, Wilson, Mahesh, Agasa Ramu
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2021
• Subjects: Bovine serum albumin; Desolvation; Ivabradine HCl; Nanoparticles; Response surface design; Nanoparticles; Bovine serum albumin; Response surface design; Ivabradine HCl; Desolvation

A modified controlled release system for cardio protective drug was developed by preparing Bovine serum albumin nanoparticles (BSA NPs) by desolvation method using Response surface methodology (RSM). Ivabradine HCl (IBH) was used as a model drug and the NPs were prepared to reduce the dose and frequ...