Single-nucleus sequencing of silkworm larval midgut reveals the immune escape strategy of BmNPV in the midgut during the late stage of infection

• Published in: Insect biochemistry and molecular biology Vol. 164; p. 104043
• Main Authors: Xia, Junming, Fei, Shigang, Huang, Yigui, Lai, Wenxuan, Yu, Yue, Liang, Lingying, Wu, Hailin, Swevers, Luc, Sun, Jingchen, Feng, Min
• Format: Journal Article
• Language: English
• Published: England 01.01.2024
• Subjects: Animals; Antiviral Agents; Bombyx - genetics; Bombyx - metabolism; Digestive System; Larva - metabolism; Nucleopolyhedroviruses - metabolism; Single-nucleus RNA sequencing; Baculovirus; Midgut; BmNPV; Silkworm

The midgut is an important barrier against microorganism invasion and proliferation, yet is the first tissue encountered when a baculovirus naturally invades the host. However, only limited knowledge is available how different midgut cell types contribute to the immune response and the clearance or...