Active dynamics and spatially coherent motion in chromosomes subject to enzymatic force dipoles

• Published in: Physical review. E Vol. 99; no. 3-1; p. 032421
• Main Authors: Put, Stefanie, Sakaue, Takahiro, Vanderzande, Carlo
• Format: Journal Article
• Language: English
• Published: United States 01.03.2019
• Subjects: Algorithms; Biomechanical Phenomena; Chromosomes - chemistry; Chromosomes - metabolism; Enzymes - chemistry; Enzymes - metabolism; Models, Chemical; Models, Genetic; Models, Molecular; Motion; Polymers - chemistry; Stochastic Processes

Inspired by recent experiments on chromosomal dynamics, we introduce an exactly solvable model for the interaction between a flexible polymer and a set of motorlike enzymes. The enzymes can bind and unbind to specific sites of the polymer and produce a dipolar force on two neighboring monomers when...