Fabrication of nanofibrous membrane using stingless bee honey and curcumin for wound healing applications

Honey and curcumin were widely used both in modern and ancient medicines. The present research work focuses on developing an antibacterial, antioxidant, biocompatible, biodegradable, non-immunogenic, and completely natural, electrospun nanofibrous wound healing membrane using curcumin and Indian hon...

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Published inJournal of drug delivery science and technology Vol. 63; p. 102271
Main Authors Samraj.S, Mark David, Kirupha, Selvaraj Dinesh, Elango, Santhini, Vadodaria, Ketankumar
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.06.2021
Subjects
Antibacterial properties
Curcumin
Electrospinning
Gelatin
Honey
Wound dressing
Electrospinning
Honey
Curcumin
Wound dressing
Antibacterial properties
Gelatin
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Abstract Honey and curcumin were widely used both in modern and ancient medicines. The present research work focuses on developing an antibacterial, antioxidant, biocompatible, biodegradable, non-immunogenic, and completely natural, electrospun nanofibrous wound healing membrane using curcumin and Indian honey collected from different regions of Tamilnadu, belonging to the same species. A nanofibrous membrane was fabricated using the combination of Honey, Curcumin, and Gelatin. The fabricated membrane was analyzed using Fourier transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM) which showed the surface morphology and the average diameter of 159.08 ± 53.88 nm of the nanofiber. The antioxidant property of the membrane was studied through scavenging the free radicals of 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS), ferric reducing antioxidant power (FRAP), and Phosphomolybdenum assays. The developed membrane showed 500% swelling and the contact angle studies showed the surface wettability of the nanofiber. The membrane was also found to be cytocompatible, enhancing adhesion and proliferation using cell proliferation studies. The in-vitro wound scratch studies showed that the wound closure happened by 18 h when treated with L929 mouse fibroblast cells, justified using the excision wound model. In-vitro kinetic studies showed a maximum release of both honey and curcumin achieved in 32 h for the membrane. The In-vivo wound healing studies demonstrated that the Honey and Curcumin loaded nanofibrous membrane indeed showed a better wound contraction of 89.05 ± 0.47% in comparison with other samples tested. [Display omitted]
AbstractList Honey and curcumin were widely used both in modern and ancient medicines. The present research work focuses on developing an antibacterial, antioxidant, biocompatible, biodegradable, non-immunogenic, and completely natural, electrospun nanofibrous wound healing membrane using curcumin and Indian honey collected from different regions of Tamilnadu, belonging to the same species. A nanofibrous membrane was fabricated using the combination of Honey, Curcumin, and Gelatin. The fabricated membrane was analyzed using Fourier transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM) which showed the surface morphology and the average diameter of 159.08 ± 53.88 nm of the nanofiber. The antioxidant property of the membrane was studied through scavenging the free radicals of 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS), ferric reducing antioxidant power (FRAP), and Phosphomolybdenum assays. The developed membrane showed 500% swelling and the contact angle studies showed the surface wettability of the nanofiber. The membrane was also found to be cytocompatible, enhancing adhesion and proliferation using cell proliferation studies. The in-vitro wound scratch studies showed that the wound closure happened by 18 h when treated with L929 mouse fibroblast cells, justified using the excision wound model. In-vitro kinetic studies showed a maximum release of both honey and curcumin achieved in 32 h for the membrane. The In-vivo wound healing studies demonstrated that the Honey and Curcumin loaded nanofibrous membrane indeed showed a better wound contraction of 89.05 ± 0.47% in comparison with other samples tested. [Display omitted]
ArticleNumber 102271
Author Kirupha, Selvaraj Dinesh
Vadodaria, Ketankumar
Elango, Santhini
Samraj.S, Mark David
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  givenname: Mark David
  surname: Samraj.S
  fullname: Samraj.S, Mark David
  organization: Centre of Excellence for Medical Textiles, The South India Textile Research Association (SITRA), Coimbatore, 641014, India
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  givenname: Selvaraj Dinesh
  surname: Kirupha
  fullname: Kirupha, Selvaraj Dinesh
  organization: Department of Applied Science and Technology, Anna University, Chennai, 600025, India
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  givenname: Santhini
  surname: Elango
  fullname: Elango, Santhini
  email: se@sitra.org.in
  organization: Centre of Excellence for Medical Textiles, The South India Textile Research Association (SITRA), Coimbatore, 641014, India
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  givenname: Ketankumar
  orcidid: 0000-0003-2752-7286
  surname: Vadodaria
  fullname: Vadodaria, Ketankumar
  email: kvarticles@live.co.uk
  organization: National Institute of Design, Paldi, Ahmedabad, Gujarat, 380007, India
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Snippet Honey and curcumin were widely used both in modern and ancient medicines. The present research work focuses on developing an antibacterial, antioxidant,...
SourceID crossref
elsevier
SourceType Aggregation Database
Publisher
StartPage 102271
SubjectTerms Antibacterial properties
Curcumin
Electrospinning
Gelatin
Honey
Wound dressing
Title Fabrication of nanofibrous membrane using stingless bee honey and curcumin for wound healing applications
URI https://dx.doi.org/10.1016/j.jddst.2020.102271
Volume 63
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