Soluble transferrin receptor-1 levels in mice do not affect iron absorption

• Published in: Acta haematologica Vol. 116; no. 4; p. 249
• Main Authors: Flanagan, Jonathan M, Peng, Hongfan, Wang, Lei, Gelbart, Terri, Lee, Pauline, Johnson Sasu, Barbra, Beutler, Ernest
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2006
• Subjects: Animals; Antigens, CD - blood; Antigens, CD - genetics; Antigens, CD - pharmacology; Female; Gene Transfer Techniques; Humans; Intestinal Absorption - drug effects; Iron - metabolism; Liver - metabolism; Male; Mice; Mice, Inbred C57BL; Receptors, Transferrin - blood; Receptors, Transferrin - genetics; Receptors, Transferrin - physiology; RNA, Messenger - analysis; Signal Transduction; Solubility

Soluble transferrin receptor-1 (sTfR1) concentrations are increased in the plasma under two conditions that are associated with increased iron absorption, i.e. iron deficiency and increased erythropoiesis. To determine the possible role of sTfR1 as a signaling mechanism for iron absorption, a hydrod...