Posttranslationally modified ornithine decarboxylase may regulate RNA polymerase I activity

• Published in: Biochemical pharmacology Vol. 31; no. 21; p. 3373
• Main Authors: Russell, D H, Manen, C A
• Format: Journal Article
• Language: English
• Published: England 01.11.1982
• Subjects: Animals; Carboxy-Lyases - pharmacology; Cell Nucleus - enzymology; DNA-Directed RNA Polymerases - metabolism; Dose-Response Relationship, Drug; Guinea Pigs; Kinetics; Liver - enzymology; Macromolecular Substances; Magnesium - pharmacology; Ornithine - pharmacology; Ornithine Decarboxylase - pharmacology; Protein Processing, Post-Translational; Putrescine - pharmacology; Rats; RNA Polymerase I - metabolism

Purified ornithine decarboxylase (EC 4.1.1.17, ODC) transamidated with four putrescine moieties on four glutamine residues through the action of transglutaminase (EC 2.3.2.13, TGase) purified from guinea pig liver, when added to isolated rat liver nuclei, stoichiometrically increased the activity of...