BS69, a corepressor interacting with ZHX1, is a bifunctional transcription factor

• Published in: Frontiers in bioscience Vol. 12; no. 1; p. 1911
• Main Author: Ogata-Kawata, Hiroko
• Format: Journal Article
• Language: English
• Published: United States 2007
• Subjects: Alternative Splicing; Animals; Binding Sites; Cell Line; Cercopithecus aethiops; Cloning, Molecular; COS Cells; Homeodomain Proteins - chemistry; Homeodomain Proteins - metabolism; Humans; Mice; Protein Structure, Tertiary; Rats; Repressor Proteins - chemistry; Repressor Proteins - genetics; Repressor Proteins - metabolism; Trans-Activators - chemistry; Trans-Activators - genetics; Trans-Activators - metabolism; Transcription Factors - chemistry; Transcription Factors - metabolism; Two-Hybrid System Techniques

Corepressor BS69 interacts with ZHX1, a member of the ZHX family having zinc-fingers and homeoboxes. In the rat, we have identified four forms of splicing variants, BS69alpha, BS69beta, BS69gamma, and BS69delta. Based on the amino acid sequence, BS69alpha corresponded to the human orthologue. BS69be...