Synthesis and characterization of oligo aminoglycosides and polyethylenimine conjugates as polymeric gene carriers

• Published in: The Korean journal of chemical engineering Vol. 40; no. 2; pp. 325 - 336
• Main Authors: Thuy, Le Thi, Mallick, Sudipta, Kim, Seongyeon, Choi, Joon Sig
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2023; Springer Nature B.V; 한국화학공학회
• Subjects: Aminoglycosides; Antibiotics; Biotechnology; Catalysis; Chemistry; Chemistry and Materials Science; Conjugates; Efficiency; Electrophoresis; Industrial Chemistry/Chemical Engineering; Low molecular weights; Materials Science; NMR; Nuclear magnetic resonance; Plasmids; Polyethyleneimine; Polymers; Titration; Toxicity; 화학공학; Kanamycin; Polyplexes; Transfection; PEI; Gene Delivery

In this study, a new kind of antibiotic drug-polymer conjugate, the kanamycin-methyl acrylate-polyethylenimine (KMP) polymer, was synthesized and characterized as gene carrier. Previous reports have shown that the modification of low molecular weight polyethylenimine (LMW-PEI) improves the transfect...