Synthesis and growth-inhibitory activities of imidazo[5,1- d ]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position - Cousin, David; Hummersone, Marc G.; Bradshaw, Tracey D.; Zhang, Jihong; Moody, Christopher J.; Foreiter, Magdalena B.; Summers, Helen S.; Lewis, William; Wheelhouse, Richard T.; Stevens, Malcolm F. G. (MedChemComm, 2018)
Keywords: Biochemistry & Molecular Biology; Biotechnology; Cell lines; Chemistry; Chemistry, Medicinal; Deoxyribonucleic acid; Derivatives; DNA; DNA methyltransferase; DNA repair; Glioma cells; Life Sciences & Biomedicine; Methylguanine; O6-methylguanine-DNA methyltransferase; Pharmacology & Pharmacy; Science & Technology; Silicon; Substitutes; Temozolomide; Tumors; CHEMISTRY; RESISTANCE; ACTIVATION; CRYSTAL; AGENTS; IMIDAZOTETRAZINES