Effect of 8 days of exercise-heat acclimation on aerobic exercise performance of men in hypobaric hypoxia
Exercise-heat acclimation (EHA) induces adaptations that improves tolerance to heat exposure. Whether adaptations from EHA can also alter responses to hypobaric hypoxia (HH) conditions remains unclear. This study assessed whether EHA can alter time-trial performance and/or incidence of acute mountai...
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Published in | American journal of physiology. Regulatory, integrative and comparative physiology Vol. 319; no. 1; pp. R114 - R122 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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01.07.2020
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Abstract | Exercise-heat acclimation (EHA) induces adaptations that improves tolerance to heat exposure. Whether adaptations from EHA can also alter responses to hypobaric hypoxia (HH) conditions remains unclear. This study assessed whether EHA can alter time-trial performance and/or incidence of acute mountain sickness (AMS) during HH exposure. Thirteen sea level (SL) resident men (SL VO
peak: 3.19 ± 0.43 l·min
) completed steady-state exercise followed by a 15-min cycle time-trial and assessment of AMS before (HH1; 3,500 m) and after (HH2) an 8-day EHA protocol (120 min; 5 km·hr
; 2% incline; 40°C and 40% RH). EHA induced lower heart rate (HR) and core temperature, and plasma volume expansion. Time-trial performance was not different between HH1 and HH2 after 2-hr(106.3±23.8 vs 101.4±23.0 kJ, p =0.71) or 24-hrs (107.3±23.4 vs 106.3±20.8 kJ, p>0.9). From HH1 to HH2, HR and oxygen saturation at the end of steady-state exercise and time-trial tests at 2 and 24-hrs was not different (p>0.05). Three of 13 volunteers developed AMS during HH1 but not during HH2, while a fourth volunteer only developed AMS during HH2. Heat shock protein 70 was not different from HH1 to HH2 at SL (1.9±0.7 vs 1.8±0.6 NII, p=0.97) or after 23-hrs (1.8±0.4 vs 1.7±0.5 NII, p=0.78) at HH. Our results indicate that this EHA protocol had little to no effect - neither beneficial nor detrimental - on exercise performance in HH. EHA may reduce AMS in those who initially developed AMS, however, studies at higher elevations having higher incidence rates are needed to confirm our findings. |
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AbstractList | Exercise-heat acclimation (EHA) induces adaptations that improve tolerance to heat exposure. Whether adaptations from EHA can also alter responses to hypobaric hypoxia (HH) conditions remains unclear. This study assessed whether EHA can alter time-trial performance and/or incidence of acute mountain sickness (AMS) during HH exposure. Thirteen sea-level (SL) resident men [SL peak oxygen consumption (V̇o
2peak
) 3.19 ± 0.43 L/min] completed steady-state exercise, followed by a 15-min cycle time trial and assessment of AMS before (HH1; 3,500 m) and after (HH2) an 8-day EHA protocol [120 min; 5 km/h; 2% incline; 40°C and 40% relative humidity (RH)]. EHA induced lower heart rate (HR) and core temperature and plasma volume expansion. Time-trial performance was not different between HH1 and HH2 after 2 h (106.3 ± 23.8 vs. 101.4 ± 23.0 kJ, P = 0.71) or 24 h (107.3 ± 23.4 vs. 106.3 ± 20.8 kJ, P > 0.9). From HH1 to HH2, HR and oxygen saturation, at the end of steady-state exercise and time-trial tests at 2 h and 24 h, were not different ( P > 0.05). Three of 13 volunteers developed AMS during HH1 but not during HH2, whereas a fourth volunteer only developed AMS during HH2. Heat shock protein 70 was not different from HH1 to HH2 at SL [1.9 ± 0.7 vs. 1.8 ± 0.6 normalized integrated intensities (NII), P = 0.97] or after 23 h (1.8 ± 0.4 vs. 1.7 ± 0.5 NII, P = 0.78) at HH. Our results indicate that this EHA protocol had little to no effect—neither beneficial nor detrimental—on exercise performance in HH. EHA may reduce AMS in those who initially developed AMS; however, studies at higher elevations, having higher incidence rates, are needed to confirm our findings. Exercise-heat acclimation (EHA) induces adaptations that improves tolerance to heat exposure. Whether adaptations from EHA can also alter responses to hypobaric hypoxia (HH) conditions remains unclear. This study assessed whether EHA can alter time-trial performance and/or incidence of acute mountain sickness (AMS) during HH exposure. Thirteen sea level (SL) resident men (SL VO peak: 3.19 ± 0.43 l·min ) completed steady-state exercise followed by a 15-min cycle time-trial and assessment of AMS before (HH1; 3,500 m) and after (HH2) an 8-day EHA protocol (120 min; 5 km·hr ; 2% incline; 40°C and 40% RH). EHA induced lower heart rate (HR) and core temperature, and plasma volume expansion. Time-trial performance was not different between HH1 and HH2 after 2-hr(106.3±23.8 vs 101.4±23.0 kJ, p =0.71) or 24-hrs (107.3±23.4 vs 106.3±20.8 kJ, p>0.9). From HH1 to HH2, HR and oxygen saturation at the end of steady-state exercise and time-trial tests at 2 and 24-hrs was not different (p>0.05). Three of 13 volunteers developed AMS during HH1 but not during HH2, while a fourth volunteer only developed AMS during HH2. Heat shock protein 70 was not different from HH1 to HH2 at SL (1.9±0.7 vs 1.8±0.6 NII, p=0.97) or after 23-hrs (1.8±0.4 vs 1.7±0.5 NII, p=0.78) at HH. Our results indicate that this EHA protocol had little to no effect - neither beneficial nor detrimental - on exercise performance in HH. EHA may reduce AMS in those who initially developed AMS, however, studies at higher elevations having higher incidence rates are needed to confirm our findings. |
Author | Yurkevicius, Beau R Coffman, Kirsten E Salgado, Roy M Bradbury, Karleigh E Luippold, Adam J Alba, Billie K Charkoudian, Nisha Fulco, Charles S Mitchell, Katherine M Mayer, Thomas A Kenefick, Robert W |
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CitedBy_id | crossref_primary_10_1152_ajpregu_00339_2021 crossref_primary_10_1016_j_jtherbio_2022_103373 crossref_primary_10_1249_MSS_0000000000002545 crossref_primary_10_1016_j_jtherbio_2024_103793 |
Cites_doi | 10.3389/fphys.2016.00078 10.1249/MSS.0b013e31827989ec 10.1152/ajpregu.00633.2010 10.1196/annals.1344.007 10.3357/ASEM.3241.2012 10.1056/NEJM200107123450206 10.1080/02688697.2018.1519108 10.3389/fphys.2017.01022 10.1249/MSS.0000000000000810 10.1152/ajpheart.00840.2003 10.1152/japplphysiol.00332.2015 10.1097/JES.0b013e31825eaa33 10.1152/japplphysiol.00495.2010 10.1113/jphysiol.2002.029108 10.1111/sms.12409 10.1080/23328940.2015.1072659 10.1097/00005768-199602000-00017 10.1152/japplphysiol.00655.2019 10.1055/s-2007-971985 10.1186/2046-7648-3-8 10.1152/ajpheart.00138.2015 10.1007/s12192-014-0528-1 10.1089/ham.2007.1016 10.1113/EP087268 10.1097/00005768-199905000-00018 10.7205/MILMED-D-14-00169 10.1152/japplphysiol.00023.2019 10.1016/S0034-5687(97)02523-1 10.1152/japplphysiol.00391.2011 10.1249/mss.0b013e31815a519b 10.1249/MSS.0b013e31826d5aa2 10.1152/ajpregu.00461.2016 10.1111/j.1749-6632.2009.05101.x 10.1152/ajpregu.00532.2007 10.7205/MILMED.170.6.451 |
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Snippet | Exercise-heat acclimation (EHA) induces adaptations that improves tolerance to heat exposure. Whether adaptations from EHA can also alter responses to... Exercise-heat acclimation (EHA) induces adaptations that improve tolerance to heat exposure. Whether adaptations from EHA can also alter responses to hypobaric... |
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Title | Effect of 8 days of exercise-heat acclimation on aerobic exercise performance of men in hypobaric hypoxia |
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