Protein disulfide isomerase redox-dependent association with p47phox: evidence for an organizer role in leukocyte NADPH oxidase activation

• Published in: Journal of leukocyte biology Vol. 90; no. 4; pp. 799 - 810
• Main Authors: de A. Paes, Antonio Marcus, Veríssimo-Filho, Sidney, Guimarães, Luciana Lopes, Silva, Ana Carolina B, Takiuti, Júlia T, Santos, Célio X C, Janiszewski, Mariano, Laurindo, Francisco R M, Lopes, Lucia R
• Format: Journal Article
• Language: English
• Published: Society for Leukocyte Biology 01.10.2011
• Subjects: neutrophil; PMA; superoxide generation

Leukocyte NADPH oxidase activity is regulated by associated protein disulfide isomerase via redox mechanisms involving p47phox. Mechanisms of leukocyte NADPH oxidase regulation remain actively investigated. We showed previously that vascular and macrophage oxidase complexes are regulated by the asso...