Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial

• Published in: Menopause (New York, N.Y.) Vol. 14; no. 5; p. 866
• Main Authors: Wu, Jian, Oka, Jun, Ezaki, Junko, Ohtomo, Takuya, Ueno, Tomomi, Uchiyama, Shigeto, Toda, Toshiya, Uehara, Mariko, Ishimi, Yoshiko
• Format: Journal Article
• Language: English
• Published: United States 01.09.2007
• Subjects: Adiposity - drug effects; Asian Continental Ancestry Group; Body Composition - drug effects; Bone and Bones - metabolism; Bone Density - drug effects; Double-Blind Method; Equol; Female; Humans; Isoflavones - administration & dosage; Isoflavones - pharmacology; Japan; Middle Aged; Osteoporosis, Postmenopausal - prevention & control; Phytoestrogens - administration & dosage; Phytoestrogens - pharmacology; Surveys and Questionnaires; Treatment Outcome; Japan

Equol is more biologically active than its precursor daidzein, which is the principal isoflavone found in soybean. There are interindividual differences in the ability to produce equol; these may lead to differences in the effects of isoflavone intervention on human health. This study aimed to inves...