Principal component analysis of a swine injury model identifies multiple phenotypes in trauma

• Published in: The journal of trauma and acute care surgery Vol. 96; no. 4; p. 634
• Main Authors: Buzzard, Lydia, Smith, Sawyer, Dixon, Alexandra, Kenny, James, Appleman, Ma, Subramanian, Sarayu, Behrens, Brandon, Rick, Elizabeth, Madtson, Brianne, Goodman, Andrew, Murphy, James, McCully, Belinda, Kanlerd, Amonpon, Trivedi, Alpa, Pati, Shibani, Schreiber, Martin
• Format: Journal Article
• Language: English
• Published: United States 01.04.2024
• Subjects: Animals; Blood Coagulation Disorders - etiology; Female; Humans; Infant; Phenotype; Principal Component Analysis; Resuscitation - methods; Swine; Thrombelastography - methods; Wounds and Injuries - complications

Trauma is the third leading cause of death in the United States and the primary cause of death for people between the ages of 1 year and 44 years. In addition to tissue damage, trauma may also activate an inflammatory state known as trauma-induced coagulopathy (TIC) that is associated with clotting...