Topoisomerase II α Gene as a Marker for Prognostic Prediction of Hepatocellular Carcinoma: A Bioinformatics Analysis

• Published in: Chinese medical sciences journal Vol. 37; no. 4; pp. 331 - 339
• Main Authors: Lu, Jin, An, Shaoguang, Ma, Junjie, Yang, Yue, Zhang, Lei, Yu, Peng, Tao, Heng, Chen, Yunfan, Zhang, Haoxuan
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 31.12.2022; Anhui Key Laboratory of Computational Medicine and Intelligent Health,Bengbu Medical College,Bengbu,Anhui 233030,China%Clinical Medical College,Bengbu Medical College,Bengbu,Anhui 233030,China%Department of Otolaryngology,First Affliated Hospital,Bengbu Medical College,Bengbu,Anhui 233030,China%Department of Surgical Oncology,Second Affliated Hospital,Bengbu Medical College,Bengbu,Anhui 233030,China%School of Basic Medicine,Bengbu Medical College,Bengbu,Anhui 233030,China; School of Basic Medicine,Bengbu Medical College,Bengbu,Anhui 233030,China
• Subjects: bioinformatics analysis; Biomarkers, Tumor - genetics; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - genetics; CD8-Positive T-Lymphocytes; Computational Biology; disease-free survival; DNA Topoisomerases, Type II - genetics; hepatocellular carcinoma; Humans; Liver Neoplasms - diagnosis; Liver Neoplasms - genetics; overall survival; Prognosis; topoisomerase II a; overall survival; disease-free survival; topoisomerase II a; bioinformatics analysis; hepatocellular carcinoma; topoisomeraseⅡα

To investigate the expression of topoisomerase II α (TOP2α) in hepatocellular carcinoma (HCC) and its role in predicting prognosis of HCC patients. We used HCC-related datasets in UALCAN, HCCDB, and cBioPortal databases to analyze the expression and mutation of TOP2α and its co-expressed genes in HC...