Nanotechnology connecting copper metabolism and tumor therapy

Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such as superoxide dismutase and cyclooxygenase. Due to the high density of the outer electron cloud of Cu, which allows the transfer of multiple electrons, Cu is often used as t...

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Published inMedComm - Biomaterials and applications Vol. 2; no. 2
Main Authors Li, Yongjuan, Dong, Ya, Zhou, Xinyao, Fan, Kelong
Format Journal Article
LanguageEnglish
Published London John Wiley & Sons, Inc 01.06.2023
Wiley
Subjects
Adenosine triphosphatase
Amino acids
Angiogenesis
Binding sites
Breast cancer
Cancer therapies
cancer therapy
Chelating agents
Chemical elements
Chemical properties
Combination therapy
Copper
copper metabolism
cuproptosis
Cytotoxicity
Damage accumulation
Drug delivery systems
Drugs
Electron clouds
Electrons
Enzymes
Growth factors
Human body
ion interference therapy
Ligands
Metabolism
Nanomaterials
Nanotechnology
Plasma
Proteins
Small intestine
Superoxide dismutase
Therapy
Toxicity
Trace elements
Tumors
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Abstract Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such as superoxide dismutase and cyclooxygenase. Due to the high density of the outer electron cloud of Cu, which allows the transfer of multiple electrons, Cu is often used as the catalytic center in various metabolic enzymes. However, both deficiency and excessive accumulation of Cu can result in irreversible damage to cells. Therefore, strategies to regulate Cu metabolism, such as Cu exhaustion and Cu supplementation, have emerged as attractive approaches in anticancer therapy, due to the potential damages caused by Cu metabolism disorders. Notably, recent advancements in nanotechnology have enabled the development of nanomaterials that can regulate Cu metabolism, making this therapy applicable in vivo. In this review, we provide a systematic discussion of the physical and chemical properties of Cu and summarize the applications of nanotechnology in Cu metabolism‐based antitumor therapy. Finally, we outline the future directions and challenges of nano‐Cu therapy, emphasizing the scientific problems and technical bottlenecks that need to be addressed for successful clinical translation. Copper metabolism is emerging as a therapeutic strategy for cancer treatment, and nanotechnology is being used to connect copper and tumor therapy. Copper deficiency and excess accumulation can cause cell damage, and nanotechnology is being used to reduce side effects and enhance therapeutic effects.
AbstractList Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such as superoxide dismutase and cyclooxygenase. Due to the high density of the outer electron cloud of Cu, which allows the transfer of multiple electrons, Cu is often used as the catalytic center in various metabolic enzymes. However, both deficiency and excessive accumulation of Cu can result in irreversible damage to cells. Therefore, strategies to regulate Cu metabolism, such as Cu exhaustion and Cu supplementation, have emerged as attractive approaches in anticancer therapy, due to the potential damages caused by Cu metabolism disorders. Notably, recent advancements in nanotechnology have enabled the development of nanomaterials that can regulate Cu metabolism, making this therapy applicable in vivo. In this review, we provide a systematic discussion of the physical and chemical properties of Cu and summarize the applications of nanotechnology in Cu metabolism‐based antitumor therapy. Finally, we outline the future directions and challenges of nano‐Cu therapy, emphasizing the scientific problems and technical bottlenecks that need to be addressed for successful clinical translation.
Abstract Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such as superoxide dismutase and cyclooxygenase. Due to the high density of the outer electron cloud of Cu, which allows the transfer of multiple electrons, Cu is often used as the catalytic center in various metabolic enzymes. However, both deficiency and excessive accumulation of Cu can result in irreversible damage to cells. Therefore, strategies to regulate Cu metabolism, such as Cu exhaustion and Cu supplementation, have emerged as attractive approaches in anticancer therapy, due to the potential damages caused by Cu metabolism disorders. Notably, recent advancements in nanotechnology have enabled the development of nanomaterials that can regulate Cu metabolism, making this therapy applicable in vivo. In this review, we provide a systematic discussion of the physical and chemical properties of Cu and summarize the applications of nanotechnology in Cu metabolism‐based antitumor therapy. Finally, we outline the future directions and challenges of nano‐Cu therapy, emphasizing the scientific problems and technical bottlenecks that need to be addressed for successful clinical translation.
Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such as superoxide dismutase and cyclooxygenase. Due to the high density of the outer electron cloud of Cu, which allows the transfer of multiple electrons, Cu is often used as the catalytic center in various metabolic enzymes. However, both deficiency and excessive accumulation of Cu can result in irreversible damage to cells. Therefore, strategies to regulate Cu metabolism, such as Cu exhaustion and Cu supplementation, have emerged as attractive approaches in anticancer therapy, due to the potential damages caused by Cu metabolism disorders. Notably, recent advancements in nanotechnology have enabled the development of nanomaterials that can regulate Cu metabolism, making this therapy applicable in vivo. In this review, we provide a systematic discussion of the physical and chemical properties of Cu and summarize the applications of nanotechnology in Cu metabolism‐based antitumor therapy. Finally, we outline the future directions and challenges of nano‐Cu therapy, emphasizing the scientific problems and technical bottlenecks that need to be addressed for successful clinical translation. Copper metabolism is emerging as a therapeutic strategy for cancer treatment, and nanotechnology is being used to connect copper and tumor therapy. Copper deficiency and excess accumulation can cause cell damage, and nanotechnology is being used to reduce side effects and enhance therapeutic effects.
Author Fan, Kelong
Dong, Ya
Li, Yongjuan
Zhou, Xinyao
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  surname: Fan
  fullname: Fan, Kelong
  email: fankelong@ibp.ac.cn
  organization: Chinese Academy of Sciences
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Snippet Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such as superoxide dismutase and...
Abstract Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such as superoxide dismutase...
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SubjectTerms Adenosine triphosphatase
Amino acids
Angiogenesis
Binding sites
Breast cancer
Cancer therapies
cancer therapy
Chelating agents
Chemical elements
Chemical properties
Combination therapy
Copper
copper metabolism
cuproptosis
Cytotoxicity
Damage accumulation
Drug delivery systems
Drugs
Electron clouds
Electrons
Enzymes
Growth factors
Human body
ion interference therapy
Ligands
Metabolism
Nanomaterials
Nanotechnology
Plasma
Proteins
Small intestine
Superoxide dismutase
Therapy
Toxicity
Trace elements
Tumors
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Title Nanotechnology connecting copper metabolism and tumor therapy
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