High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix
Microbubbles with a negligible shell are of utmost importance in the study of harmonic ultrasound contrast agents. The purpose of this study was to collect and quantify experimental pulsation footage of gas microbubbles released from tablet matrix under sonication. Radii were measured as a function...
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Published in | Current directions in biomedical engineering Vol. 9; no. 1; pp. 25 - 28 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
De Gruyter
01.09.2023
De Gruyter GmbH |
Series | Proceedings of the 57th Annual Meeting of the German Society of Biomedical Engineering (26 – 28 September 2023, Duisburg) |
Subjects | |
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Abstract | Microbubbles with a negligible shell are of utmost importance in the study of harmonic ultrasound contrast agents. The purpose of this study was to collect and quantify experimental pulsation footage of gas microbubbles released from tablet matrix under sonication. Radii were measured as a function of time of 50 microbubbles that had been released from tablet matrix and were subjected to 3-cycle pulses of 1-MHz ultrasound with a 0.3-MPa peak-negative pressure. The size distribution was measured, as well as pre- and postsonication radii. The experimental footage showed proof of asymmetric buckling, but also of excursion-only behaviour. The former phenomenon has been attributed to a surplus of material accumulated on the microbubble-liquid interfaces, whilst the latter phenomenon has been associated with the presence of incompressible material inside the microbubbles. The postsonication resting radii of 41 microbubbles had become less compared to the corresponding pre-sonication radii. The opposite effect was observed with eight microbubbles in the same size range. This feasibility study confirmed that the gas microbubbles released from tablet matrix may pulsate asymmetrically. Thus, they might be suitable tracers for harmonic imaging. |
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AbstractList | Microbubbles with a negligible shell are of utmost importance in the study of harmonic ultrasound contrast agents. The purpose of this study was to collect and quantify experimental pulsation footage of gas microbubbles released from tablet matrix under sonication. Radii were measured as a function of time of 50 microbubbles that had been released from tablet matrix and were subjected to 3-cycle pulses of 1-MHz ultrasound with a 0.3-MPa peak-negative pressure. The size distribution was measured, as well as pre- and postsonication radii. The experimental footage showed proof of asymmetric buckling, but also of excursion-only behaviour. The former phenomenon has been attributed to a surplus of material accumulated on the microbubble-liquid interfaces, whilst the latter phenomenon has been associated with the presence of incompressible material inside the microbubbles. The postsonication resting radii of 41 microbubbles had become less compared to the corresponding pre-sonication radii. The opposite effect was observed with eight microbubbles in the same size range. This feasibility study confirmed that the gas microbubbles released from tablet matrix may pulsate asymmetrically. Thus, they might be suitable tracers for harmonic imaging. Abstract Microbubbles with a negligible shell are of utmost importance in the study of harmonic ultrasound contrast agents. The purpose of this study was to collect and quantify experimental pulsation footage of gas microbubbles released from tablet matrix under sonication. Radii were measured as a function of time of 50 microbubbles that had been released from tablet matrix and were subjected to 3-cycle pulses of 1-MHz ultrasound with a 0.3-MPa peak-negative pressure. The size distribution was measured, as well as pre- and postsonication radii. The experimental footage showed proof of asymmetric buckling, but also of excursion-only behaviour. The former phenomenon has been attributed to a surplus of material accumulated on the microbubble-liquid interfaces, whilst the latter phenomenon has been associated with the presence of incompressible material inside the microbubbles. The postsonication resting radii of 41 microbubbles had become less compared to the corresponding pre-sonication radii. The opposite effect was observed with eight microbubbles in the same size range. This feasibility study confirmed that the gas microbubbles released from tablet matrix may pulsate asymmetrically. Thus, they might be suitable tracers for harmonic imaging. Abstract Microbubbles with a negligible shell are of utmost importance in the study of harmonic ultrasound contrast agents. The purpose of this study was to collect and quantify experimental pulsation footage of gas microbubbles released from tablet matrix under sonication. Radii were measured as a function of time of 50 microbubbles that had been released from tablet matrix and were subjected to 3-cycle pulses of 1-MHz ultrasound with a 0.3-MPa peak-negative pressure. The size distribution was measured, as well as pre- and postsonication radii. The experimental footage showed proof of asymmetric buckling, but also of excursion-only behaviour. The former phenomenon has been attributed to a surplus of material accumulated on the microbubble-liquid interfaces, whilst the latter phenomenon has been associated with the presence of incompressible material inside the microbubbles. The postsonication resting radii of 41 microbubbles had become less compared to the corresponding pre-sonication radii. The opposite effect was observed with eight microbubbles in the same size range. This feasibility study confirmed that the gas microbubbles released from tablet matrix may pulsate asymmetrically. Thus, they might be suitable tracers for harmonic imaging. |
Author | Xinyue, Hu Otake, Naoyuki Ketolainen, Jarkko Kudo, Nobuki Anderton, Nicole Carlson, Craig S. Postema, Michiel Sorjonen, Joona |
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Keywords | Micro-crystalline cellulose buckling MCC tablet matrix controlled gas release Rayleigh-Plesset equation |
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SubjectTerms | buckling controlled gas release Life Sciences MCC tablet matrix Micro-crystalline cellulose Pharmaceutical sciences Pharmacology Rayleigh-Plesset equation |
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Title | High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix |
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