Continuous Infusion of β-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration
To investigate the toxicity of β-amyloid protein, a component of the senile plaques in Alzheimer’s disease, it was infused into the cerebral ventricle of rats for 14 days by a mini-osmotic pump. Performances in the water maze and passive avoidance tasks in β-amyloid protein-treated rats were impaire...
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Published in | Japanese journal of pharmacology Vol. 73; no. 1; pp. 51 - 57 |
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Format | Journal Article |
Language | English |
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01.01.1997
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Abstract | To investigate the toxicity of β-amyloid protein, a component of the senile plaques in Alzheimer’s disease, it was infused into the cerebral ventricle of rats for 14 days by a mini-osmotic pump. Performances in the water maze and passive avoidance tasks in β-amyloid protein-treated rats were impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after the cessation of the infusion. However, the learning impairment was recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after the cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Furthermore, β-amyloid protein altered the staining in the nuclei of hippocampal cells for only 2 weeks after the cessation. These results suggest that β-amyloid protein produces some damage in the central nervous system in vivo. |
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AbstractList | To investigate the toxicity of beta-amyloid protein, a component of the senile plaques in Alzheimer's disease, it was infused into the cerebral ventricle of rats for 14 days by a mini-osmotic pump. Performances in the water maze and passive avoidance tasks in beta-amyloid protein-treated rats were impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after the cessation of the infusion. However, the learning impairment was recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after the cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Furthermore, beta-amyloid protein altered the staining in the nuclei of hippocampal cells for only 2 weeks after the cessation. These results suggest that beta-amyloid protein produces some damage in the central nervous system in vivo. To investigate the toxicity of β-amyloid protein, a component of the senile plaques in Alzheimer’s disease, it was infused into the cerebral ventricle of rats for 14 days by a mini-osmotic pump. Performances in the water maze and passive avoidance tasks in β-amyloid protein-treated rats were impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after the cessation of the infusion. However, the learning impairment was recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after the cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Furthermore, β-amyloid protein altered the staining in the nuclei of hippocampal cells for only 2 weeks after the cessation. These results suggest that β-amyloid protein produces some damage in the central nervous system in vivo. |
Author | Nabeshima, Toshitaka Fukuta, Taneo Hasegawa, Takaaki Nitta, Atsumi |
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Cites_doi | 10.1016/0022-510X(82)90045-4 10.1016/S0378-4347(00)84006-2 10.1016/S0197-4580(96)80261-2 10.1620/tjem.174.241 10.1016/0006-2952(88)90524-2 10.1016/S0006-291X(05)81222-7 10.1073/pnas.82.12.4245 10.1016/0022-510X(82)90155-1 10.1016/0304-3940(94)90239-9 10.1016/0197-4580(92)90062-3 10.1016/0006-8993(91)91553-D 10.1016/0092-8674(88)90462-X 10.1007/BF01244936 10.1523/JNEUROSCI.12-02-00376.1992 10.1046/j.1471-4159.1996.66031113.x 10.1016/0014-2999(93)90616-P 10.1146/annurev.bi.58.070189.001443 |
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Keywords | Learning and memory Cholinergic neuron Alzheimer’s disease Amyloid protein Glial fibrillary acidic protein |
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References | Freeman (10.1254/jjp.60.51_bib17) 1988; 37 Show (10.1254/jjp.60.51_bib3) 1988; 133 Pike (10.1254/jjp.60.51_bib15) 1991; 563 Nitta (10.1254/jjp.60.51_bib11) 1993; 250 Wilcock (10.1254/jjp.60.51_bib6) 1982; 57 Nitta (10.1254/jjp.60.51_bib12) 1993; 93 Kaneda (10.1254/jjp.60.51_bib13) 1985; 341 Wilcock (10.1254/jjp.60.51_bib4) 1982; 56 Mattson (10.1254/jjp.60.51_bib19) 1992; 12 Abraham (10.1254/jjp.60.51_bib2) 1988; 52 Nabeshima (10.1254/jjp.60.51_bib10) 1991; 175 Itoh (10.1254/jjp.60.51_bib14) 1996; 17 Waite (10.1254/jjp.60.51_bib16) 1992; 13 Nitta (10.1254/jjp.60.51_bib7) 1994; 170 Goldberg (10.1254/jjp.60.51_bib18) 1987; 243 Nabeshima (10.1254/jjp.60.51_bib8) 1994; 174 Müller-Hill (10.1254/jjp.60.51_bib5) 1989; 58 Masters (10.1254/jjp.60.51_bib1) 1985; 82 Itoh (10.1254/jjp.60.51_bib9) 1996; 66 |
References_xml | – volume: 57 start-page: 407 year: 1982 ident: 10.1254/jjp.60.51_bib6 article-title: Alzheimer’s disease: Correlation of cortical choline acetyltransferae activity with the severity of dementia and histological abnormalities publication-title: J Neurol Sci doi: 10.1016/0022-510X(82)90045-4 contributor: fullname: Wilcock – volume: 341 start-page: 23 year: 1985 ident: 10.1254/jjp.60.51_bib13 article-title: Highly sensitive assay for choline acetyltransferase activity by high-performance liquid chromatography with electrochemical detection publication-title: J Chromatogr doi: 10.1016/S0378-4347(00)84006-2 contributor: fullname: Kaneda – volume: 17 start-page: 17 year: 1996 ident: 10.1254/jjp.60.51_bib14 article-title: Neuronal dysfunction in rats infused β-amyloid protein into cerebral ventricle publication-title: Neurobiol Aging doi: 10.1016/S0197-4580(96)80261-2 contributor: fullname: Itoh – volume: 174 start-page: 241 year: 1994 ident: 10.1254/jjp.60.51_bib8 article-title: Memory impairment and neuronal dysfunction induced by β-amyloid protein in rats publication-title: Tohoku J Exp Med doi: 10.1620/tjem.174.241 contributor: fullname: Nabeshima – volume: 37 start-page: 1153 year: 1988 ident: 10.1254/jjp.60.51_bib17 article-title: Microsomal metabolism of acetonitrile to cyanide publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(88)90524-2 contributor: fullname: Freeman – volume: 243 start-page: 784 year: 1987 ident: 10.1254/jjp.60.51_bib18 article-title: N-Methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture publication-title: J Pharmacol Exp Ther contributor: fullname: Goldberg – volume: 175 start-page: 215 year: 1991 ident: 10.1254/jjp.60.51_bib10 article-title: Memory impairment and morphological changes in rats induced by active fragment of anti-nerve growth factor-antibody publication-title: Biochem Biophys Res Commun doi: 10.1016/S0006-291X(05)81222-7 contributor: fullname: Nabeshima – volume: 133 start-page: 456 year: 1988 ident: 10.1254/jjp.60.51_bib3 article-title: The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer’s disease publication-title: Am J Pathol contributor: fullname: Show – volume: 82 start-page: 4245 year: 1985 ident: 10.1254/jjp.60.51_bib1 article-title: Amyloid plaque core protein in Alzheimer disease and Down syndrome publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.82.12.4245 contributor: fullname: Masters – volume: 56 start-page: 343 year: 1982 ident: 10.1254/jjp.60.51_bib4 article-title: Plaques, tangles and dementia. A quantitative study publication-title: J Neurol Sci doi: 10.1016/0022-510X(82)90155-1 contributor: fullname: Wilcock – volume: 170 start-page: 63 year: 1994 ident: 10.1254/jjp.60.51_bib7 article-title: β-Amyloid protein-induced Alzheimer’s disease model publication-title: Neurosci Lett doi: 10.1016/0304-3940(94)90239-9 contributor: fullname: Nitta – volume: 13 start-page: 595 year: 1992 ident: 10.1254/jjp.60.51_bib16 article-title: Solvent effects on beta protein toxicity in vivo publication-title: Neurobiol Aging doi: 10.1016/0197-4580(92)90062-3 contributor: fullname: Waite – volume: 563 start-page: 311 year: 1991 ident: 10.1254/jjp.60.51_bib15 article-title: In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity publication-title: Brain Res doi: 10.1016/0006-8993(91)91553-D contributor: fullname: Pike – volume: 52 start-page: 487 year: 1988 ident: 10.1254/jjp.60.51_bib2 article-title: Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer’s disease publication-title: Cell doi: 10.1016/0092-8674(88)90462-X contributor: fullname: Abraham – volume: 93 start-page: 37 year: 1993 ident: 10.1254/jjp.60.51_bib12 article-title: Development of plasticity of brain function with repeated trainings and passage of time after basal forebrain lesions in rats publication-title: J Neural Transm [G-sect] doi: 10.1007/BF01244936 contributor: fullname: Nitta – volume: 12 start-page: 376 year: 1992 ident: 10.1254/jjp.60.51_bib19 article-title: β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity publication-title: J Neurosci doi: 10.1523/JNEUROSCI.12-02-00376.1992 contributor: fullname: Mattson – volume: 66 start-page: 1113 year: 1996 ident: 10.1254/jjp.60.51_bib9 article-title: Dysfunction of cholinergic and dopaminergic neuronal systems in β-amyloid protein-infused rats publication-title: J Neurochem doi: 10.1046/j.1471-4159.1996.66031113.x contributor: fullname: Itoh – volume: 250 start-page: 23 year: 1993 ident: 10.1254/jjp.60.51_bib11 article-title: Effects of oral administration of a stimulator for nerve growth factor synthesis in basal forebrain-lesioned rats publication-title: Eur J Pharmacol doi: 10.1016/0014-2999(93)90616-P contributor: fullname: Nitta – volume: 58 start-page: 287 year: 1989 ident: 10.1254/jjp.60.51_bib5 article-title: Molecular biology of Alzheimer’s disease publication-title: Annu Rev Biochem doi: 10.1146/annurev.bi.58.070189.001443 contributor: fullname: Müller-Hill |
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Snippet | To investigate the toxicity of β-amyloid protein, a component of the senile plaques in Alzheimer’s disease, it was infused into the cerebral ventricle of rats... To investigate the toxicity of beta-amyloid protein, a component of the senile plaques in Alzheimer's disease, it was infused into the cerebral ventricle of... To investigate the toxicity of beta -amyloid protein, a component of the senile plaques in Alzheimer's disease, it was infused into the cerebral ventricle of... |
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SubjectTerms | Alzheimer’s disease Amyloid beta-Peptides - toxicity Amyloid protein Animals Avoidance Learning - drug effects Choline O-Acetyltransferase - antagonists & inhibitors Cholinergic neuron Corpus Striatum - drug effects Corpus Striatum - enzymology Frontal Lobe - drug effects Frontal Lobe - enzymology Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - analysis Hippocampus - drug effects Hippocampus - enzymology Hippocampus - ultrastructure Immunohistochemistry Injections, Intraventricular Learning and memory Male Maze Learning - drug effects Nerve Degeneration - drug effects Parietal Lobe - drug effects Parietal Lobe - enzymology Rats Rats, Wistar |
Title | Continuous Infusion of β-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration |
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