Obesity and impairment of pancreatic β‐cell function in early adulthood, independent of obesity age of onset: The Santiago Longitudinal Study

• Published in: Diabetes/metabolism research and reviews Vol. 37; no. 2; pp. e3371 - n/a
• Main Authors: Burrows, Raquel, Correa‐Burrows, Paulina, Bunout, Daniel, Barrera, Gladys, Rogan, José, Kim, Elissa, Blanco, Estela, Gahagan, Sheila
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Inc 01.02.2021; Wiley Subscription Services, Inc
• Subjects: Adiponectin; Adolescents; Age of Onset; Beta cells; BMI trajectory; Child development; Children; Chile - epidemiology; Fatty liver; Humans; Insulin; Insulin resistance; Insulin-Secreting Cells - physiology; Longitudinal Studies; Obesity; Obesity - epidemiology; Obesity - physiopathology; Pancreas; Teenagers; Young Adult; Young adults; β‐cell function; Chile; β-cell function; insulin resistance; BMI trajectory; obesity
• ISSN: 1520-7552; 1520-7560; 1520-7560
• DOI: 10.1002/dmrr.3371

Aim We investigated the relation of time of onset and length of obesity with biomarkers of β‐cell function in early adulthood in an infancy cohort. Material and methods In 1039 23‐year‐olds, body‐mass index (BMI) was measured at multiple time‐points from enrollment. BMI trajectories were interpolate...