Mitochondrial displacement loop region single nucleotide polymorphisms and mitochondrial DNA copy number associated with risk of ankylosing spondylitis

• Published in: International journal of rheumatic diseases Vol. 26; no. 11; pp. 2157 - 2162
• Main Authors: Zhang, Jingjing, Peng, Chenxing, Xu, Shuo, Zhao, Yufei, Zhang, Xiaoyun, Zhang, Shasha, Guo, Zhanjun
• Format: Journal Article
• Language: English
• Published: Richmond Wiley Subscription Services, Inc 01.11.2023
• Subjects: Alleles; Ankylosing spondylitis; Arthritis; Copy number; Fluorescent indicators; Mitochondrial DNA; Oxidative stress; Pathogenesis; Patients; Polymerase chain reaction; Reactive oxygen species; Single-nucleotide polymorphism

AimThe pathogenesis of ankylosing spondylitis (AS) seems to be associated with genetics, the environment, heredity, and oxidative stress. Single nucleotide polymorphisms (SNPs) in the displacement loop (D‐loop) region of mitochondrial DNA (mtDNA) and mtDNA copy number were investigated for their cor...