Selective blockade of Ca2+ permeable AMPA receptors in CA1 area of rat hippocampus

• Published in: Neuroscience Vol. 144; no. 1; pp. 88 - 99
• Main Authors: Buldakova, S.L, Kim, K.K, Tikhonov, D.B, Magazanik, L.G
• Format: Journal Article
• Language: English
• Published: United States 05.01.2007
• Subjects: Adamantane - analogs & derivatives; Adamantane - pharmacology; Animals; Bicuculline - pharmacology; Calcium - metabolism; Electric Stimulation; Excitatory Amino Acid Antagonists - pharmacology; Excitatory Postsynaptic Potentials - drug effects; GABA Antagonists - pharmacology; Hippocampus - cytology; Hippocampus - drug effects; Hippocampus - metabolism; In Vitro Techniques; Interneurons - drug effects; Interneurons - metabolism; Neurology; Pyramidal Cells - drug effects; Pyramidal Cells - physiology; Rats; Receptors, AMPA - antagonists & inhibitors; Receptors, AMPA - metabolism; Synapses - drug effects; Synapses - metabolism; PP; synaptic network; inhibitory postsynaptic current; PSC; radiatum–lacunosum moleculare; hippocampus; perforant path; inhibition; Schaffer collateral; Ca 2+ permeability; AMPAR; N-methyl- d-aspartate receptor; postsynaptic current; SC; AMPA receptor; excitation; IPSC; NMDAR; R-LM; AMPA receptors; EPSC; excitatory postsynaptic current

Abstract Using whole cell patch-clamp recording from pyramidal cells and interneurons in the CA1 area of hippocampal slices, the effect of IEM-1460, a selective channel blocker of Ca2+ permeable AMPA receptors (AMPARs), on postsynaptic currents (PSCs) was studied. Excitatory postsynaptic currents (E...