Influence of serum levels on leukemic cell destruction by the ether lipid ET-18-OCH3

The effect of serum on the antineoplastic action of the alkyl-lysophospholipid 1-octadecyl-2-O-methyl-sn-glycerol-3-phosphocholine (ET-18-OCH3) was studied in two human leukemia cell lines, HL60 and K562, and in leukemic cells of patients. Decreasing amounts of serum in the culture medium enhanced t...

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Published inLeukemia research Vol. 19; no. 6; pp. 417 - 425
Main Authors Heesbeen, E C, Rijksen, G, van Heugten, H G, Verdonck, L F
Format Journal Article
LanguageEnglish
Published England 01.06.1995
Subjects
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - toxicity
Biological Factors - blood
Biological Factors - pharmacology
Bone Marrow Cells
Bone Marrow Purging - methods
Cell Division - drug effects
Cell Survival - drug effects
Culture Media, Serum-Free
Dose-Response Relationship, Drug
Drug Interactions
Humans
Leukemia - drug therapy
Leukemia - metabolism
Leukemia, Erythroblastic, Acute - drug therapy
Leukemia, Erythroblastic, Acute - metabolism
Leukemia, Myeloid, Acute - blood
Phospholipid Ethers - pharmacokinetics
Phospholipid Ethers - toxicity
Serum Albumin, Bovine - pharmacology
Tumor Cells, Cultured - drug effects
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Abstract The effect of serum on the antineoplastic action of the alkyl-lysophospholipid 1-octadecyl-2-O-methyl-sn-glycerol-3-phosphocholine (ET-18-OCH3) was studied in two human leukemia cell lines, HL60 and K562, and in leukemic cells of patients. Decreasing amounts of serum in the culture medium enhanced the cytotoxic action of ET-18-OCH3 dramatically in both cell lines and in the leukemic cells, as measured by cell survival and proliferation. Uptake of ET-18-OCH3 was likewise increased at reduced serum levels. Similar effects were obtained when fetal calf serum (FCS) in the culture medium was substituted by bovine serum albumin (BSA, fatty acid free). Selectivity of the alkyl-lysophospholipid at reduced serum or BSA level was demonstrated by clonogenic assays of normal marrow progenitor cells. Our study provides an optimalization of the purging conditions in autologous bone marrow transplantation, by using a low concentration of BSA during ET-18-OCH3 treatment (20 micrograms/ml for 4 h) in serum-free culture medium.
AbstractList The effect of serum on the antineoplastic action of the alkyl-lysophospholipid 1-octadecyl-2-O-methyl-sn-glycerol-3-phosphocholine (ET-18-OCH3) was studied in two human leukemia cell lines, HL60 and K562, and in leukemic cells of patients. Decreasing amounts of serum in the culture medium enhanced the cytotoxic action of ET-18-OCH3 dramatically in both cell lines and in the leukemic cells, as measured by cell survival and proliferation. Uptake of ET-18-OCH3 was likewise increased at reduced serum levels. Similar effects were obtained when fetal calf serum (FCS) in the culture medium was substituted by bovine serum albumin (BSA, fatty acid free). Selectivity of the alkyl-lysophospholipid at reduced serum or BSA level was demonstrated by clonogenic assays of normal marrow progenitor cells. Our study provides an optimalization of the purging conditions in autologous bone marrow transplantation, by using a low concentration of BSA during ET-18-OCH3 treatment (20 micrograms/ml for 4 h) in serum-free culture medium.
Author Rijksen, G
Heesbeen, E C
Verdonck, L F
van Heugten, H G
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Snippet The effect of serum on the antineoplastic action of the alkyl-lysophospholipid 1-octadecyl-2-O-methyl-sn-glycerol-3-phosphocholine (ET-18-OCH3) was studied in...
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SubjectTerms Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - toxicity
Biological Factors - blood
Biological Factors - pharmacology
Bone Marrow Cells
Bone Marrow Purging - methods
Cell Division - drug effects
Cell Survival - drug effects
Culture Media, Serum-Free
Dose-Response Relationship, Drug
Drug Interactions
Humans
Leukemia - drug therapy
Leukemia - metabolism
Leukemia, Erythroblastic, Acute - drug therapy
Leukemia, Erythroblastic, Acute - metabolism
Leukemia, Myeloid, Acute - blood
Phospholipid Ethers - pharmacokinetics
Phospholipid Ethers - toxicity
Serum Albumin, Bovine - pharmacology
Tumor Cells, Cultured - drug effects
Title Influence of serum levels on leukemic cell destruction by the ether lipid ET-18-OCH3
URI https://www.ncbi.nlm.nih.gov/pubmed/7596155
Volume 19
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