Fatty Acid Synthesis of an Eicosapentaenoic Acid-Producing Bacterium: De Novo Synthesis, Chain Elongation, and Desaturation Systems

• Published in: Journal of biochemistry (Tokyo) Vol. 122; no. 2; pp. 467 - 473
• Main Authors: Watanabe, Kazuo, Yazawa, Kazunaga, Kondo, Kiyosi, Kawaguchi, Akihiko
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.08.1997
• Subjects: Acetyl Coenzyme A - metabolism; Acyl Carrier Protein - pharmacology; Cerulenin - pharmacology; de novo fatty acid synthesis; eicosapentaenoic acid; Eicosapentaenoic Acid - biosynthesis; Enzyme Inhibitors - pharmacology; fatty acid chain elongation; Fatty Acid Desaturases - metabolism; fatty acid desaturation; Fatty Acids - biosynthesis; Fatty Acids - metabolism; Gram-Negative Facultatively Anaerobic Rods - metabolism; Malonyl Coenzyme A - metabolism; marine bacterium; Models, Chemical; NAD - pharmacology; NADP - pharmacology

The fatty acid synthesis systems of a Shewanella sp., strain SCRC-2738, that produces a large amount of eicosapentaenoic acid were investigated. Two kinds of fatty acid synthesis system, de novo synthesis and chain elongation ones, were detected in the cytosol. The de novo synthesis system required...