L-type Ca2+ channels, Ca2+-induced Ca2+ release, and BKCa channels in airway stretch-induced contraction

• Published in: European journal of pharmacology Vol. 696; no. 1-3; pp. 161 - 165
• Main Authors: Hernandez, Jeremy Mark, Janssen, Luke Jeffrey
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 05.12.2012
• Subjects: Airway hyperresponsiveness; arteries; Bronchoconstriction; calcium; carbachol; cattle; Deep inspiration; mechanical stress; potassium channels; potassium chloride; ryanodine receptors; smooth muscle; Bronchoconstriction; Airway hyperresponsiveness; Deep inspiration

Resistance arteries constrict in response to mechanical stress. This response is myogenic in nature, and reliant on membrane depolarization, activation of L-type Ca2+ channels, Ca2+-induced Ca2+-release and large conductance Ca2+-dependent K+ channels (BKCa). Airway smooth muscle is also affected by...