Comparison of the Molecular International Prognostic Scoring System (IPSS-M) and Revised International Prognostic Scoring System (IPSS-R) in predicting the prognosis of patients with myelodysplastic neoplasms treated with decitabine
Abstract Background Molecular International Prognostic Scoring System (IPSS-M) is a newly developed prognostic model for myelodysplastic neoplasms (MDS), but has not yet been used widely. In this study, we aimed to compare the IPSS-M with the traditional Revised International Prognostic Scoring Syst...
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Published in | Oncologie (Paris, France) Vol. 26; no. 2; pp. 323 - 328 |
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Format | Journal Article |
Language | English |
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Abstract | Abstract
Background
Molecular International Prognostic Scoring System (IPSS-M) is a newly developed prognostic model for myelodysplastic neoplasms (MDS), but has not yet been used widely. In this study, we aimed to compare the IPSS-M with the traditional Revised International Prognostic Scoring System (IPSS-R) in predicting the prognosis of decitabine treated-MDS patients.
Patients and methods
This retrospective cohort study was conducted on 19 newly diagnosed MDS patients who were examined for 51 gene mutations and received decitabine treatment. The survival analysis, including overall survival (OS), progression-free survival (PFS), and leukemia-free survival (LFS), was performed using the Kaplan–Meier method. Comparisons between the risk groups were carried out according to the IPSS-R and IPSS-M models.
Results
Among the 19 MDS patients, 12 (63.2 %) showed myeloid gene mutations, with the highest frequency of mutations in
ASXL1
,
RUNX1
,
SRSF2
,
TET2
, and
TP53
(15.8 %). Survival analysis found that the OS was significantly different between the risk groups of both IPSS-R and IPSS-M models, but the PFS and LFS showed significant differences between the risk groups in only the IPSS-M model. The PFS of the moderate, high, and very high-risk groups were 34.66, 25.00, and 15.33 months (p=0.031); respectively. The LFS of the moderate, high, and very high-risk groups were 39.20, 25.00, and 18.37 months, (p=0.039); respectively.
Conclusions
Our results found that IPSS-M was better than IPSS-R in predicting the PFS and LFS of decitabine-treated MDS patients, IPSS-M may be superior to IPSS-R in predicting the prognosis of MDS patients. |
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AbstractList | Abstract
Background
Molecular International Prognostic Scoring System (IPSS-M) is a newly developed prognostic model for myelodysplastic neoplasms (MDS), but has not yet been used widely. In this study, we aimed to compare the IPSS-M with the traditional Revised International Prognostic Scoring System (IPSS-R) in predicting the prognosis of decitabine treated-MDS patients.
Patients and methods
This retrospective cohort study was conducted on 19 newly diagnosed MDS patients who were examined for 51 gene mutations and received decitabine treatment. The survival analysis, including overall survival (OS), progression-free survival (PFS), and leukemia-free survival (LFS), was performed using the Kaplan–Meier method. Comparisons between the risk groups were carried out according to the IPSS-R and IPSS-M models.
Results
Among the 19 MDS patients, 12 (63.2 %) showed myeloid gene mutations, with the highest frequency of mutations in
ASXL1
,
RUNX1
,
SRSF2
,
TET2
, and
TP53
(15.8 %). Survival analysis found that the OS was significantly different between the risk groups of both IPSS-R and IPSS-M models, but the PFS and LFS showed significant differences between the risk groups in only the IPSS-M model. The PFS of the moderate, high, and very high-risk groups were 34.66, 25.00, and 15.33 months (p=0.031); respectively. The LFS of the moderate, high, and very high-risk groups were 39.20, 25.00, and 18.37 months, (p=0.039); respectively.
Conclusions
Our results found that IPSS-M was better than IPSS-R in predicting the PFS and LFS of decitabine-treated MDS patients, IPSS-M may be superior to IPSS-R in predicting the prognosis of MDS patients. |
Author | Vu, Minh Phuong Nguyen, Ha Thanh Bach, Quoc Khanh Tran, Tuan Anh Vu, Duc Binh Duong, Quoc Chinh Nguyen, Quang Hao |
Author_xml | – sequence: 1 givenname: Quang Hao surname: Nguyen fullname: Nguyen, Quang Hao organization: Clinical Hematology Department, Thai Nguyen National Hospital, Thai Nguyen City, Vietnam – sequence: 2 givenname: Minh Phuong orcidid: 0000-0001-5473-557X surname: Vu fullname: Vu, Minh Phuong email: vuminhphuong@yahoo.com organization: Hematology and Blood Transfusion Center, Bach Mai Hospital, Hanoi, Vietnam – sequence: 3 givenname: Tuan Anh surname: Tran fullname: Tran, Tuan Anh organization: Department of Molecular Cytogenetics, National Institute of Hematology and Blood Transfusion, Hanoi, Vietnam – sequence: 4 givenname: Quoc Chinh surname: Duong fullname: Duong, Quoc Chinh organization: Department of Molecular Cytogenetics, National Institute of Hematology and Blood Transfusion, Hanoi, Vietnam – sequence: 5 givenname: Duc Binh surname: Vu fullname: Vu, Duc Binh organization: Department of General Hematology, National Institute of Hematology and Blood Transfusion, Hanoi, Vietnam – sequence: 6 givenname: Ha Thanh surname: Nguyen fullname: Nguyen, Ha Thanh organization: Department of Hematology, Hanoi Medical University, Hanoi, Vietnam – sequence: 7 givenname: Quoc Khanh surname: Bach fullname: Bach, Quoc Khanh organization: Department of Chemotherapy, National Institute of Hematology and Blood Transfusion, Hanoi, Vietnam |
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Background
Molecular International Prognostic Scoring System (IPSS-M) is a newly developed prognostic model for myelodysplastic neoplasms (MDS), but... |
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SubjectTerms | decitabine leukemia-free survival (LFS) Molecular International Prognostic Scoring System (IPSS-M) myelodysplastic neoplasms (MDS) prognosis progression-free survival (PFS) |
Title | Comparison of the Molecular International Prognostic Scoring System (IPSS-M) and Revised International Prognostic Scoring System (IPSS-R) in predicting the prognosis of patients with myelodysplastic neoplasms treated with decitabine |
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