Quantitative Analysis of Tranexamic Acid Effects on Ecchymosis in Rhinoplasty

• Published in: Archives of facial plastic surgery Vol. 24; no. 3; p. 228
• Main Authors: Cristel, Robert T, Demesh, Daniel, Patel, Manish J, Shah, Anil R
• Format: Journal Article
• Language: English
• Published: Chicago American Medical Association 01.06.2022
• Subjects: Antifibrinolytic agents; Blood coagulation; Color; Intravenous administration; Nose; Plastic surgery; Quantitative analysis; Rhinoplasty; Seizures; Side effects; Subgroups
• DOI: 10.1089/fpsam.2021.0032
• ISSN: 2168-6076

Background: Many methods have been described to reduce postoperative ecchymosis in rhinoplasty with tranexamic acid (TXA) remaining controversial. TXA remains a consideration for surgeons, however, may have serious side effects, including seizures, blood clots, and vision changes. Methods: A prospective study of primary rhinoplasty patients was performed from March 2019 to June 2019. TXA was used in 50 patients and postoperative ecchymosis was compared with 50 control patients. Adobe Photoshop was used to quantitate postoperative ecchymosis using multiple objective color scales. Results: One hundred subjects were enrolled in the study. Eighty-four females and 16 males were included. Photographs were taken on postoperative day 7. There were no significant differences among any of the Red, Green, Blue (RGB) and L*a*b* color subgroups with p > 0.05. There were no adverse events with TXA. Conclusions: In this study, TXA did not reduce postoperative ecchymosis in rhinoplasty when used both through intravenous and intraoperative injections.