Reduction of senescence‐associated beta‐galactosidase activity by vitamin E in human fibroblasts depends on subjects’ age and cell passage number

• Published in: BioFactors (Oxford) Vol. 46; no. 4; pp. 665 - 674
• Main Authors: Ricciarelli, Roberta, Azzi, Angelo, Zingg, Jean‐Marc
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.07.2020
• Subjects: alpha‐tocopherol; CD36 scavenger receptor; exosomes; extracellular vesicles; gene expression; lysosome; senescence; signal transduction; vitamin E

Cell senescence is due to the permanent cell cycle arrest that occurs as a result of the inherent limited replicative capacity toward the Hayflick limit (replicative senescence), or in response to various stressors (stress‐induced premature senescence, SIPS). With the acquisition of the senescence‐a...