Absorption, Distribution, and Excretion of the Investigational Agent Orteronel (TAK-700) in Healthy Male Subjects: A Phase 1, Open-Label, Single-Dose Study - Suri, Ajit; Pusalkar, Sandeepraj; Li, Yuexian; Prakash, Shimoga (Clinical pharmacology in drug development, 2016)
Keywords: absorption; Adult; Area Under Curve; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors - adverse effects; Cytochrome P-450 Enzyme Inhibitors - pharmacokinetics; distribution; excretion; Half-Life; Humans; Imidazoles - adverse effects; Imidazoles - pharmacokinetics; Male; metastatic castration-resistant prostate cancer; Naphthalenes - adverse effects; Naphthalenes - pharmacokinetics; orteronel; Steroid 17-alpha-Hydroxylase - antagonists & inhibitors; Tandem Mass Spectrometry; Young Adult; metastatic castration-resistant prostate cancer; excretion; distribution; absorption; orteronel