Bupleurum chinense exerts a mild antipyretic effect on LPS-induced pyrexia rats involving inhibition of peripheral TNF-α production

• Published in: Journal of ethnopharmacology Vol. 310; p. 116375
• Main Authors: Kang, Yuan, Gao, Yuan, Li, Ximeng, Guo, Xinwei, Liu, Zhuangzhuang, Li, Wenjing, Wei, Jianhe, Qi, Yun
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.06.2023
• Subjects: Animals; Antipyretic effect; Antipyretics - pharmacology; Antipyretics - therapeutic use; blood serum; Bupleurum; Bupleurum chinense; Bupleurum chinense DC; complement; Complement activation; Endogenous pyrogen TNF-α; Endotoxemia; fever; Fever - chemically induced; Fever - drug therapy; Interleukin-6; intravenous injection; lipopolysaccharides; Lipopolysaccharides - toxicity; Mice; monocytes; Rats; Saikosaponins; species; traditional medicine; Tumor Necrosis Factor-alpha; Complement activation; Endogenous pyrogen TNF-α; Saikosaponins; Bupleurum chinense DC; Antipyretic effect

Bupleuri Radix, the dried roots of Bupleurum chinense DC. (BC) or Bupleurum scorzonerifolium Willd., is one of the most frequently used traditional Chinese medicines. As the species in Xiao-Chai-Hu decoction, BC has been used as an antipyretic medicine with a long history. However, its antipyretic c...