Bupleurum chinense exerts a mild antipyretic effect on LPS-induced pyrexia rats involving inhibition of peripheral TNF-α production - Kang, Yuan; Gao, Yuan; Li, Ximeng; Guo, Xinwei; Liu, Zhuangzhuang; Li, Wenjing; Wei, Jianhe; Qi, Yun (Journal of ethnopharmacology, 2023)
Keywords: Animals; Antipyretic effect; Antipyretics - pharmacology; Antipyretics - therapeutic use; blood serum; Bupleurum; Bupleurum chinense; Bupleurum chinense DC; complement; Complement activation; Endogenous pyrogen TNF-α; Endotoxemia; fever; Fever - chemically induced; Fever - drug therapy; Interleukin-6; intravenous injection; lipopolysaccharides; Lipopolysaccharides - toxicity; Mice; monocytes; Rats; Saikosaponins; species; traditional medicine; Tumor Necrosis Factor-alpha; Complement activation; Endogenous pyrogen TNF-α; Saikosaponins; Bupleurum chinense DC; Antipyretic effect