Assessing the diagnostic power of variables measured with a detection limit

• Published in: Computational statistics Vol. 31; no. 4; pp. 1287 - 1303
• Main Authors: Jia, Bochao, Chang, Yuan-chin Ivan, Wang, Zhanfeng
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2016; Springer Nature B.V
• Subjects: Approximation; Biomarkers; Computational mathematics; Diagnostic systems; Diagnostics; Economic Theory/Quantitative Economics/Mathematical Methods; Estimates; Estimating techniques; Estimators; Mathematical analysis; Mathematical models; Mathematics and Statistics; Numerical analysis; Original Paper; Probability and Statistics in Computer Science; Probability Theory and Stochastic Processes; Random variables; Simulation; Statistics; Strategy; Studies; Variables; Limit of detection; Partial AUC; ROC curve; AUC

The phenomenon of the limit of detection (LoD) often happens in many practical situations because of technique and instrument limitations. In the literature, some reports show that, in general, to apply conventional methods to evaluate the diagnostic power of variables while ignoring LoD could be se...