Use of the DNA-repair host-mediated assay for determining the organ distribution of genotoxic factors in mice treated orally with nitro-aromatic compounds

• Published in: Mutation Research/Environmental Mutagenesis and Related Subjects Vol. 164; no. 1; pp. 9 - 17
• Main Authors: Knasmüller, S., Kerklaan, P., Mohn, G.R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.1986
• Subjects: 5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole - analysis; 5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole - pharmacology; Aniline Compounds - analysis; Animals; Anthelmintics - analysis; Anthelmintics - pharmacology; Antiprotozoal Agents - analysis; Antiprotozoal Agents - pharmacology; Diphenylamine - analogs & derivatives; Diphenylamine - analysis; Diphenylamine - pharmacology; DNA Repair - drug effects; Escherichia coli - drug effects; Female; Isothiocyanates; Metronidazole - analysis; Metronidazole - pharmacology; Mice; Mutagenicity Tests; Nitrofurans - analysis; Thiocyanates - analysis; Thiocyanates - pharmacology; Tissue Distribution; PBS; NRS-agar; amoscanate; metronidazole; SQ 18 506; PEP-S

The distribution of genotoxic factors in various organs of mice treated orally with nitro-aromatic compounds of actual or potential use as chemotherapeutic (antiprotozoal and anthelminthical) agents was investigated in the DNA-repair host-mediated assay, with mice as host animals and a pair of E. co...