Varying oncomodulin mRNA abundance in developing placenta and solid tumors

An antisense RNA probe complementary to rat oncomodulin mRNA has been prepared by run-off transcription. Blots of RNA isolated from tumors arising from both a chemically-induced hepatoma or virally transformed sarcomas, when probed with this antisense RNA, identified a common single hybridizable RNA...

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Published inCancer letters Vol. 40; no. 2; pp. 151 - 160
Main Authors Gillen, M.F., Brewer, L.M., Macmanus, J.P.
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 15.06.1988
Elsevier
Subjects
Animals
Biological and medical sciences
Calcium-Binding Proteins - genetics
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Female
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
mRNA abundance
Neoplasms, Experimental - analysis
Oncomodulin
Placenta
Placenta - analysis
Pregnancy
Rats
RNA, Messenger - analysis
Solid tumors
Placenta
Solid tumors
mRNA abundance
Oncomodulin
Molecular hybridization
RNA
Rat
Sarcoma
Rodentia
Antisense RNA
Northern blotting
Vertebrata
Mammalia
Messenger RNA
Liver cell carcinoma
Tumor
Molecular probe
Nucleic acid
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Abstract An antisense RNA probe complementary to rat oncomodulin mRNA has been prepared by run-off transcription. Blots of RNA isolated from tumors arising from both a chemically-induced hepatoma or virally transformed sarcomas, when probed with this antisense RNA, identified a common single hybridizable RNA of approx. 750 nucleotides, corresponding in size to that found in blots of RNA from rat placenta. Quantitative densitometry of dot blot autoradiographs allowed for relative measurements of oncomodulin mRNA in the various tumors. The increased sensitivity of detection afforded by the antisense probe permitted the measurement of oncomodulin mRNA in the developing placenta, which was not possible using DNA probes. In both tumors and placenta, a plot of mRNA versus protein revealed a direct relationship suggesting transcriptional control of oncomodulin abundance.
AbstractList An antisense RNA probe complementary to rat oncomodulin mRNA has been prepared by run-off transcription. Blots of RNA isolated from tumors arising from both a chemically-induced hepatoma or virally transformed sarcomas, when probed with this antisense RNA, identified a common single hybridizable RNA of approx. 750 nucleotides, corresponding in size to that found in blots of RNA from rat placenta. Quantitative densitometry of dot blot autoradiographs allowed for relative measurements of oncomodulin mRNA in the various tumors. The increased sensitivity of detection afforded by the antisense probe permitted the measurement of oncomodulin mRNA in the developing placenta, which was not possible using DNA probes. In both tumors and placenta, a plot of mRNA versus protein revealed a direct relationship suggesting transcriptional control of oncomodulin abundance.
Author Gillen, M.F.
Macmanus, J.P.
Brewer, L.M.
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Issue 2
Keywords Placenta
Solid tumors
mRNA abundance
Oncomodulin
Molecular hybridization
RNA
Rat
Sarcoma
Rodentia
Antisense RNA
Northern blotting
Vertebrata
Mammalia
Messenger RNA
Liver cell carcinoma
Tumor
Molecular probe
Nucleic acid
Language English
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PublicationTitle Cancer letters
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PublicationYear 1988
Publisher Elsevier Ireland Ltd
Elsevier
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  article-title: Detection of oncomodulin, an oncodevelopmental protein in human placenta and choriocarcinoma cell lines
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Snippet An antisense RNA probe complementary to rat oncomodulin mRNA has been prepared by run-off transcription. Blots of RNA isolated from tumors arising from both a...
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StartPage 151
SubjectTerms Animals
Biological and medical sciences
Calcium-Binding Proteins - genetics
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Female
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
mRNA abundance
Neoplasms, Experimental - analysis
Oncomodulin
Placenta
Placenta - analysis
Pregnancy
Rats
RNA, Messenger - analysis
Solid tumors
Title Varying oncomodulin mRNA abundance in developing placenta and solid tumors
URI https://dx.doi.org/10.1016/0304-3835(88)90005-5
https://www.ncbi.nlm.nih.gov/pubmed/3383173
https://search.proquest.com/docview/78260747
Volume 40
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