Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs are believed to be related to mutational activation of receptor tyrosine kinases, KIT, or platelet-derived growth factor receptor-alpha. The coexistence of GISTs with other neoplasms h...

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Published inTumori Vol. 95; no. 2; pp. 240 - 242
Main Authors Sonmez, Mehmet, Arslan, Mehmet, Cobanoglu, Umit, Kavgaci, Halil, Ozbas, Hasan Mucahit, Aydin, Fazil, Ovali, Ercument, Omay, Serdar Bedii
Format Journal Article
LanguageEnglish
Published United States 01.03.2009
Subjects
Aged
Anemia, Refractory - etiology
Anemia, Refractory - pathology
Biopsy
Bone Marrow - pathology
Female
Gastrointestinal Stromal Tumors - complications
Gastrointestinal Stromal Tumors - pathology
Humans
Leukemia, Myeloid, Acute - complications
Leukemia, Myeloid, Acute - pathology
Myelodysplastic Syndromes - complications
Myelodysplastic Syndromes - pathology
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Abstract Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs are believed to be related to mutational activation of receptor tyrosine kinases, KIT, or platelet-derived growth factor receptor-alpha. The coexistence of GISTs with other neoplasms has been extensively addressed in the literature. The most common second neoplasms are colorectal cancer, prostate cancer, and neoplasms derived from lymphoid tissue. In this case report, we describe a patient affected by GIST and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia. The clinicopathological characteristics of the patient are discussed and the literature is reviewed.
AbstractList Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs are believed to be related to mutational activation of receptor tyrosine kinases, KIT, or platelet-derived growth factor receptor-alpha. The coexistence of GISTs with other neoplams has been extensively addressed in the literature. The most common second neoplasms are colorectal cancer, prostate cancer, and neoplasms derived from lymphoid tissue. In this case report, we describe a patient affected by GIST and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia. The clinicopathological characteristics of the patient are discussed and the literature is reviewed.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs are believed to be related to mutational activation of receptor tyrosine kinases, KIT, or platelet-derived growth factor receptor-alpha. The coexistence of GISTs with other neoplasms has been extensively addressed in the literature. The most common second neoplasms are colorectal cancer, prostate cancer, and neoplasms derived from lymphoid tissue. In this case report, we describe a patient affected by GIST and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia. The clinicopathological characteristics of the patient are discussed and the literature is reviewed.
Author Aydin, Fazil
Sonmez, Mehmet
Ovali, Ercument
Cobanoglu, Umit
Ozbas, Hasan Mucahit
Omay, Serdar Bedii
Arslan, Mehmet
Kavgaci, Halil
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CitedBy_id crossref_primary_10_3892_ol_2016_4353
crossref_primary_10_1016_j_medcle_2017_06_045
crossref_primary_10_1016_j_medcli_2017_06_010
crossref_primary_10_3748_wjg_v25_i30_4261
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SubjectTerms Aged
Anemia, Refractory - etiology
Anemia, Refractory - pathology
Biopsy
Bone Marrow - pathology
Female
Gastrointestinal Stromal Tumors - complications
Gastrointestinal Stromal Tumors - pathology
Humans
Leukemia, Myeloid, Acute - complications
Leukemia, Myeloid, Acute - pathology
Myelodysplastic Syndromes - complications
Myelodysplastic Syndromes - pathology
Title Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia
URI https://www.ncbi.nlm.nih.gov/pubmed/19579873
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