Experimental models to study the physiology, pathophysiology, and pharmacology of the lower urinary tract

• Published in: Journal of pharmacological and toxicological methods Vol. 49; no. 3; pp. 201 - 210
• Main Author: Fry, C.H
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2004
• Subjects: Animals; Bladder denervation; Bladder obstruction; Cells, Cultured; Cultured cells; Electromyography; Electrophysiology; Humans; Intracellular ions; Isolated cells; Isometric Contraction - drug effects; Isometric Contraction - physiology; Isometric tension; Models, Theoretical; Multicellular preparations; Muscle Contraction - drug effects; Muscle Contraction - physiology; Muscle, Smooth - cytology; Muscle, Smooth - drug effects; Muscle, Smooth - physiology; Urinary Bladder - cytology; Urinary Bladder - drug effects; Urinary Bladder - physiology; Urinary Bladder Diseases - physiopathology; Urinary Tract - physiopathology; Urothelium - cytology; Urothelium - drug effects; Multicellular preparations; Bladder obstruction; Intracellular ions; Electrophysiology; Cultured cells; Isometric tension; Electromyography; Isolated cells; Bladder denervation

The lower urinary tract is subject to a number of functional disorders, the most common of which, in humans, is bladder overactivity. To understand its pathophysiological basis, several in vitro and in vivo methodologies have been developed. In vitro tension recording from multicellular strips is in...