Vascular Extracellular Superoxide Dismutase Activity in Patients With Coronary Artery Disease Relation to Endothelium-Dependent Vasodilation

• Published in: Circulation (New York, N.Y.) Vol. 101; no. 19; pp. 2264 - 2270
• Main Authors: Landmesser, Ulf, Merten, Roland, Spiekermann, Stephan, Büttner, Karsten, Drexler, Helmut, Hornig, Burkhard
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 16.05.2000
• Subjects: Adult; Aged; Antioxidants - pharmacology; Ascorbic Acid - pharmacology; Coronary Disease - enzymology; Coronary Disease - physiopathology; Coronary Vessels - enzymology; Drug Combinations; Endothelium, Vascular - physiopathology; Enzyme Inhibitors - pharmacology; Extracellular Space - enzymology; Humans; Hypercholesterolemia - enzymology; Hypercholesterolemia - physiopathology; Male; Middle Aged; omega-N-Methylarginine - pharmacology; Radial Artery - drug effects; Radial Artery - physiopathology; Reactive Oxygen Species - physiology; Superoxide Dismutase - metabolism; Vasodilation - drug effects; Vasodilation - physiology

Background —Increased inactivation of nitric oxide by oxygen free radicals contributes to endothelial dysfunction in patients with coronary artery disease (CAD). We therefore determined the activity of extracellular superoxide dismutase (EC-SOD), the major antioxidant enzyme system of the vessel wal...