The dopamine D1 receptor positive allosteric modulator, DETQ, improves cognition and social interaction in aged mice and enhances cortical and hippocampal acetylcholine efflux

• Published in: Behavioural brain research Vol. 459; p. 114766
• Main Authors: Rajagopal, Lakshmi, Huang, Mei, Mahjour, Sanaz, Ryan, Chelsea, Elzokaky, Ahmad, Svensson, Kjell A., Meltzer, H.Y.
• Format: Journal Article
• Language: English
• Published: Netherlands 29.02.2024
• Subjects: DETQ; Microdialysis; Social interaction; Aging; Acetylcholine; Cognition; D1PAM; Dopamine D1 receptor; Novel object recognition; Alzheimer’s; Parkinson’s

Dopamine (DA) D1 and D2 receptors (Rs) are critical for cognitive functioning. D1 positive allosteric modulators (D1PAMs) activate D1Rs without desensitization or an inverted U-shaped dose response curve. DETQ, [2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methyl-3,...