Plumbagin Induces Reactive Oxygen Species and Endoplasmic Reticulum Stress-related Cell Apoptosis in Human Oral Squamous Cell Carcinoma

• Published in: Anticancer research Vol. 44; no. 3; pp. 1173 - 1182
• Main Authors: CHEN, PO-HAN, LU, HSEIN-KUN, RENN, TING-YI, CHANG, TSUNG-MING, LEE, CHIA-JUNG, TSAO, YA-TING, CHUANG, PO-KAI, LIU, JU-FANG
• Format: Journal Article
• Language: English
• Published: Greece 01.03.2024
• Subjects: ER stress; apoptosis; plumbagin; Oral squamous cell carcinoma; ROS

Oral squamous cell carcinoma (OSCC), a major malignancy in Taiwan, is an invasive epithelial neoplasm resulting in a low survival rate. Current treatments do not prevent OSCC progression, and antitumor therapies should be improved. Plumbagin, a natural compound extracted from Plumbago zeylanica L.,...