Application of a simple and rapid LC-MS/MS method for determination of danshensu in human plasma for an oral pharmacokinetic study of Danshen granules in Chinese healthy subjects

• Published in: Analytical methods Vol. 6; no. 6; pp. 1956 - 1962
• Main Authors: Fu, Shujun, Li, Lifeng, Qiu, Feng, Wang, Baohe, Du, Wuxun, Feng, Limin
• Format: Journal Article
• Language: English
• Published: 01.01.2014
• Subjects: chloramphenicol; danshensu; ethyl acetate; formic acid; granules; hematologic tests; liquid chromatography; liquid-liquid extraction; monitoring; oral administration; pharmacokinetics; tandem mass spectrometry

A simple and rapid liquid chromatography-electrospray ionization-tandem mass spectrometry method is developed and validated for the determination of danshensu in plasma of Chinese healthy subjects after oral administration of Danshen granules. After liquid–liquid extraction with ethyl acetate, dansh...