A novel sensor to estimate the prevalence of hypochlorous (HOCl) toxicity in individuals with type 2 diabetes and dyslipidemia

• Published in: Clinica chimica acta Vol. 458; pp. 144 - 153
• Main Authors: Ghoshal, Kakali, Das, Sangita, Aich, Krishnendu, Goswami, Shyamaprosad, Chowdhury, Subhankar, Bhattacharyya, Maitree
• Format: Journal Article
• Language: English
• Published: Netherlands 01.07.2016
• Subjects: Diabetes Mellitus, Type 2 - metabolism; Dyslipidemias - metabolism; Fluorescent Dyes - analysis; Fluorescent Dyes - chemistry; Humans; Hypochlorous Acid - analysis; Hypochlorous Acid - metabolism; Hypochlorous Acid - poisoning; Quinolines - chemistry; Reactive Oxygen Species - analysis; Reactive Oxygen Species - metabolism; Rhodamines - analysis; Rhodamines - chemistry; Hypochlorous acid; Diabetes mellitus; Dyslipidemia; Fluorescent probe; Reactive oxygen species (ROS)

Oxidative stress is common in type 2 diabetes. It is characterised by increased levels of reactive oxygen species (ROS), of which hypochlorous acid (HOCl) is an important component. Type 2 diabetes is characterised not only by hyperglycemia, but also by dyslipidemia. It probably underlies both the d...