Iron excretion from the goblet cells of the small intestine in man. An additional regulatory mechanism in iron homeostasis?

Iron-excreting goblet cells were observed by chance in a patient with myelogenic leukaemia. Duodenal and jejunal biopsies from patients with a wide spectrum of disorders have therefore been examined retrospectively after staining with Perl's iron method. Thirty-seven of the patients had iron-ex...

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Bibliographic Details
Published inScandinavian journal of gastroenterology Vol. 15; no. 8; p. 1013
Main Authors Refsum, S B, Schreiner, B
Format Journal Article
LanguageEnglish
Published England 01.01.1980
Subjects
Gastrointestinal Diseases - metabolism
Gastrointestinal Diseases - pathology
Homeostasis
Humans
Intestine, Small - metabolism
Intestine, Small - pathology
Iron - metabolism
Jejunum - metabolism
Jejunum - pathology
Leukemia, Myeloid, Acute - metabolism
Leukemia, Myeloid, Acute - pathology
Macrophages - metabolism
Male
Middle Aged
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Summary:Iron-excreting goblet cells were observed by chance in a patient with myelogenic leukaemia. Duodenal and jejunal biopsies from patients with a wide spectrum of disorders have therefore been examined retrospectively after staining with Perl's iron method. Thirty-seven of the patients had iron-excreting goblet cells. The presence of iron has been confirmed by X-ray microanalysis and by electron microscopic histochemistry. In addition to iron-excreting goblet cells, most of these patients had iron-containing macrophages in lamina propria. This may indicate that the two types of cells co-operate in the excretion process. It is suggested that iron excretion may be part of the common iron balance mechanism.
ISSN:0036-5521
1502-7708
DOI:10.3109/00365528009181806