Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians

• Published in: Mitochondrion Vol. 7; no. 4; pp. 267 - 272
• Main Authors: Iwata, Nahoko, Zhang, Jin, Atzmon, Gil, Leanza, Suzanne, Cho, Jaehyoung, Chomyn, Anne, Burk, Robert D., Barzilai, Nir, Attardi, Giuseppe
• Format: Journal Article
• Language: English
• Published: Netherlands 01.07.2007
• Subjects: Adult; Aged; Aged, 80 and over; Aging - genetics; DNA, Mitochondrial - genetics; Female; Humans; Italy - epidemiology; Jews - genetics; Leukocytes - metabolism; Male; Middle Aged; Mitochondrial Diseases - epidemiology; Mitochondrial Diseases - genetics; Mutation - genetics; Replication Origin - genetics; Italy

Our previous observation that a mitochondrial DNA (mtDNA) homoplasmic C150T transition adjacent to the heavy strand replication origin at position 151 is greatly increased in frequency in Italian centenarians, as compared to the rest of the population, has prompted us to analyze a genetically distin...