Cytokine and chemokine networks: pathways to antiviral defense

The complex interplays between cytokines and chemokines are emerging as key communication signals in the shaping of innate and adaptive immune responses against foreign pathogens, including viruses. In particular, the virus-induced expression of cytokine and chemokine profiles drives the recruitment...

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Bibliographic Details
Published inCurrent topics in microbiology and immunology Vol. 303; p. 29
Main Authors Salazar-Mather, T P, Hokeness, K L
Format Journal Article
LanguageEnglish
Published Germany 2006
Subjects
Animals
Chemokine CCL2 - physiology
Chemokine CCL4
Chemokine CXCL9
Chemokines - physiology
Chemokines, CXC - physiology
Cytokines - physiology
Herpesviridae Infections - immunology
Humans
Interferon Type I - physiology
Interferon-gamma - biosynthesis
Killer Cells, Natural - immunology
Liver - immunology
Macrophage Inflammatory Proteins - physiology
Mice
Muromegalovirus
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Summary:The complex interplays between cytokines and chemokines are emerging as key communication signals in the shaping of innate and adaptive immune responses against foreign pathogens, including viruses. In particular, the virus-induced expression of cytokine and chemokine profiles drives the recruitment and activation of immune effector cells to sites of tissue infection. Under the conditions of infection with murine cytomegalovirus (MCMV), a herpesvirus with pathogenic potential, early immune functions are essential in the control of virus replication and virus-induced pathology. The coordinated MCMV-induced cytokine and chemokine responses promote effective natural killer (NK) cell recruitment and function, and ultimately MCMV clearance. The studies highlighted in this chapter illustrate in vivo pathways mediated by innate cytokines in regulating chemokine responses that are vital for localized antiviral defenses.
ISSN:0070-217X
DOI:10.1007/978-3-540-33397-5_2