Role of ionic liquids in ibuprofen-based eutectic systems: Aqueous solubility, permeability, human cytotoxicity, hemolytic activity and anti-inflammatory activity

• Published in: Journal of molecular liquids Vol. 404; p. 124966
• Main Authors: Bastos, Joana C., Manuela Gaspar, Maria, Pereiro, Ana B., Araújo, João M.M.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.06.2024
• Subjects: Anti-inflammatory activity; Bioavailability; Cytotoxicity; Eutectic Systems; Hemocompatibility; Hydrogen bonding; Ibuprofen; Ionic liquids; Ionicity; Polarity; Eutectic Systems; Hemocompatibility; Ibuprofen; Ionic liquids; Ionicity; Polarity; Cytotoxicity; Anti-inflammatory activity; Bioavailability; Hydrogen bonding

[Display omitted] •Twelve pharmaceutically active eutectics based on ibuprofen conjugated with imidazolium-based ILs or cholinium salt at different molar ratio were prepared.•An upgrade of the aqueous solubility (water and biological simulated fluids) for the ibuprofen-based eutectics relatively to...