Development of tolerance to the anticonvulsant effects of clobazam

The anticonvulsant properties of the 1,5-benzodiazepine clobazam were studied in mice during and after chronic treatment at two different dose levels. Pentylenetetrazol given by slow intravenous infusion was used as the convulsant stimulus. Tolerance to the anticonvulsant effects was observed; this...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 94; no. 1-2; p. 155
Main Authors Gent, J P, Haigh, J R
Format Journal Article
LanguageEnglish
Published Netherlands 14.10.1983
Subjects
Animals
Anti-Anxiety Agents
Anticonvulsants
Benzodiazepines
Benzodiazepinones - pharmacology
Clobazam
Drug Tolerance
Male
Mice
Pentylenetetrazole - antagonists & inhibitors
Time Factors
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Summary:The anticonvulsant properties of the 1,5-benzodiazepine clobazam were studied in mice during and after chronic treatment at two different dose levels. Pentylenetetrazol given by slow intravenous infusion was used as the convulsant stimulus. Tolerance to the anticonvulsant effects was observed; this was rapid in onset and could be overcome by increasing the dose of clobazam.
ISSN:0014-2999
DOI:10.1016/0014-2999(83)90454-5