Prenatal MgSO4 treatment modifies the erythrocyte band 3 in preterm neonates

• Published in: Pharmacological research Vol. 53; no. 4; pp. 347 - 352
• Main Authors: Gulczynska, Ewa, Gadzinowski, Janusz, Wilczynski, Jan, Zylinska, Ludmila
• Format: Journal Article
• Language: English
• Published: Netherlands 01.04.2006
• Subjects: Adenosine Triphosphate - blood; Adult; Anion Exchange Protein 1, Erythrocyte - metabolism; Erythrocyte Membrane - drug effects; Erythrocyte Membrane - metabolism; Erythrocytes - drug effects; Erythrocytes - metabolism; Female; Fetal Blood; Humans; Infant, Newborn - blood; Lipid Peroxidation - drug effects; Magnesium - blood; Magnesium Sulfate - pharmacology; Membrane Lipids - blood; Phosphorylation - drug effects; Pregnancy; Prenatal Exposure Delayed Effects

Magnesium sulphate that is widely used to prevent preterm labour or treatment for imminent eclampsia is also suggested to decrease a cerebral palsy in preterm newborns. However, the molecular mechanism of MgSO4 protection in fetus remains unknown. Since Mg2+ very rapidly crosses the placenta, we ass...