Interleukin 23 receptor gene polymorphisms and their role in the inflammatory status of rheumatoid arthritis patients in an Iranian population

• Published in: International journal of rheumatic diseases Vol. 26; no. 2; pp. 259 - 266
• Main Authors: Abbasifard, Mitra, Mirzaei, Mohammad Reza, Abade, Mahsa, Bagheri‐Hosseinabadi, Zahra
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.02.2023
• Subjects: Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - genetics; Case-Control Studies; Cytokines; Gene expression; Gene Frequency; Gene polymorphism; Genetic Predisposition to Disease; Genotype; Humans; IL‐23R, IL‐23, IL‐17A; Inflammation; Interleukin 23; Interleukin-17 - genetics; Interleukin-23 - genetics; Iran; Leukocytes, Mononuclear; Pathogenesis; Peripheral blood mononuclear cells; Polymorphism, Single Nucleotide; Receptors, Interleukin - genetics; Rheumatoid arthritis; Serum levels; Single-nucleotide polymorphism; Iran; single nucleotide polymorphism; rheumatoid arthritis; IL-23R, IL-23, IL-17A

Background Several investigations have disclosed the involvement of the interleukin (IL)‐23/IL‐17 pathway in rheumatoid arthritis (RA) pathogenesis. Here we investigated the association of single nucleotide polymorphisms (SNPs) in the IL23 receptor (IL23R) gene with RA risk. In addition, the role of...