The Novel Application of EUK‐134 in Retinal Degeneration: Preventing Mitochondrial Oxidative Stress‐Triggered Retinal Pigment Epithelial Cell Apoptosis by Suppressing MAPK/p53 Signaling Pathway

• Published in: Environmental toxicology Vol. 40; no. 1; pp. 88 - 100
• Main Authors: Tsou, Shang‐Chun, Chuang, Chen‐Ju, Hsu, Chin‐Lin, Chen, Tzu‐Chun, Yeh, Jui‐Hsuan, Wang, Meilin, Wang, Inga, Chang, Yuan‐Yen, Lin, Hui‐Wen
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2025; Wiley Subscription Services, Inc
• Subjects: adults; age‐related macular degeneration (AMD); Animals; Antioxidant properties; antioxidants; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; blindness; Caspase; caspase-3; caspase-9; Catalase; Cell Line; cell lines; Cell viability; Deformation; Deformation effects; Degeneration; Depolarization; ecotoxicology; epithelial cells; Epithelium; EUK‐134; Eye diseases; Humans; In vivo methods and tests; Inhibitors; Iodates; Iodates - toxicity; Macular degeneration; Male; MAP kinase; MAP Kinase Signaling System - drug effects; MAPK signaling pathway; Membrane potential; Mice; Mice, Inbred BALB C; Mitochondria; Mitochondria - drug effects; Organometallic Compounds - pharmacology; Oxidative stress; Oxidative Stress - drug effects; p53 Protein; Pigments; protein synthesis; Retina; Retinal degeneration; Retinal Degeneration - drug therapy; Retinal Degeneration - pathology; Retinal Degeneration - prevention & control; Retinal pigment epithelium; retinal pigment epithelium (RPE); Retinal Pigment Epithelium - drug effects; Retinal Pigment Epithelium - pathology; Retinopathy; Salicylates - pharmacology; Signal transduction; Signal Transduction - drug effects; Sodium; sodium iodate (NaIO3); Tumor Suppressor Protein p53 - metabolism; age‐related macular degeneration (AMD); retinal pigment epithelium (RPE); EUK‐134; sodium iodate (NaIO3); MAPK signaling pathway

ABSTRACT Age‐related macular degeneration (AMD), a leading cause of blindness, is characterized by mitochondrial dysfunction of retinal pigment epithelium (RPE) cells. EUK‐134 is a mimetic of SOD2 and catalase, widely used for its antioxidant properties in models of light‐induced damage or oxidative...