The Novel Application of EUK‐134 in Retinal Degeneration: Preventing Mitochondrial Oxidative Stress‐Triggered Retinal Pigment Epithelial Cell Apoptosis by Suppressing MAPK/p53 Signaling Pathway - Tsou, Shang‐Chun; Chuang, Chen‐Ju; Hsu, Chin‐Lin; Chen, Tzu‐Chun; Yeh, Jui‐Hsuan; Wang, Meilin; Wang, Inga; Chang, Yuan‐Yen; Lin, Hui‐Wen (Environmental toxicology, 2025)
Keywords: adults; age‐related macular degeneration (AMD); Animals; Antioxidant properties; antioxidants; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; blindness; Caspase; caspase-3; caspase-9; Catalase; Cell Line; cell lines; Cell viability; Deformation; Deformation effects; Degeneration; Depolarization; ecotoxicology; epithelial cells; Epithelium; EUK‐134; Eye diseases; Humans; In vivo methods and tests; Inhibitors; Iodates; Iodates - toxicity; Macular degeneration; Male; MAP kinase; MAP Kinase Signaling System - drug effects; MAPK signaling pathway; Membrane potential; Mice; Mice, Inbred BALB C; Mitochondria; Mitochondria - drug effects; Organometallic Compounds - pharmacology; Oxidative stress; Oxidative Stress - drug effects; p53 Protein; Pigments; protein synthesis; Retina; Retinal degeneration; Retinal Degeneration - drug therapy; Retinal Degeneration - pathology; Retinal Degeneration - prevention & control; Retinal pigment epithelium; retinal pigment epithelium (RPE); Retinal Pigment Epithelium - drug effects; Retinal Pigment Epithelium - pathology; Retinopathy; Salicylates - pharmacology; Signal transduction; Signal Transduction - drug effects; Sodium; sodium iodate (NaIO3); Tumor Suppressor Protein p53 - metabolism; age‐related macular degeneration (AMD); retinal pigment epithelium (RPE); EUK‐134; sodium iodate (NaIO3); MAPK signaling pathway