Calcitonin gene-related peptide-induced vasodilation in the human forearm is antagonized by CGRP8-37: evaluation of a human in vivo pharmacodynamic model

• Published in: Clinical pharmacology and therapeutics Vol. 79; no. 3; p. 263
• Main Authors: Vanmolkot, Floris H M, Van der Schueren, Bart J E P, de Hoon, Jan N J M
• Format: Journal Article
• Language: English
• Published: United States 01.03.2006
• Subjects: Adult; Calcitonin Gene-Related Peptide - antagonists & inhibitors; Calcitonin Gene-Related Peptide - pharmacology; Calcium Channel Blockers - pharmacology; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Forearm - blood supply; Hemodynamics - drug effects; Humans; Male; Nitroprusside - pharmacology; Peptide Fragments - pharmacology; Regional Blood Flow - drug effects; Reproducibility of Results; Vasodilation - drug effects; Vasodilator Agents - antagonists & inhibitors; Vasodilator Agents - pharmacology; Verapamil - pharmacology

The aims of this study were to assess the potential of CGRP8-37, the C-terminal fragment of calcitonin gene-related peptide (CGRP), to inhibit CGRP-induced vasodilation in the human forearm and to evaluate a pharmacodynamic model to aid the clinical development of novel CGRP-receptor antagonists. Fo...